Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Mouse (tested or 100% immunogen sequence identity)
IHC - Frozen (1:3000)
Specificity and Use
Mouse Lymph node stroma
The antigen is a (glyco-)protein of 140kDa m.w. which is located within the cytoplasm and on the cell surface. The epitope has not been further characterized. Antigen distribution: Isolated cells: In the cytospin preparation of thioglycollate stimulated peritoneal exudate cells MOMA-2 detects an antigen as distinct cytoplasmic spots. MOMA-2 detects monocytes of the peripheral blood and a subpopulation of bone marrow cells Tissue sections MOMA-2 detects typical tissue macrophages as does the anti F4/80-specific clone BM8 (pan macrophage marker). However, different staining patterns are visible as shown below. The most predominant difference can be observed in T-cell areas and follicles of peripheral lymphoid organs where the anti F4/80 clone BM8 is negative. Specificity: Mouse: monocytes and macrophages. Other species: not tested.
Lyophilized from PBS pH 7.2, 5mg/ml BSA, 0.1% sodium azide