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Anti-MOB1B / MOBKL1A Antibody (aa177-206) LS-C98948

Ordering

Wt. Vol. Conc. Price
- 400 µl - $305
Inquire for larger quantities

LSBio (Direct) LSBio (Direct)
206-374-1102
866-206-6909
Orders@LSBio.com
 

Most Popular MOB1B / MOBKL1A Antibodies

Anti-MOB1B / MOBKL1A Antibody (aa101-150) IHC-plus™ LS-B9147
Rabbit Polyclonal (IgG) to Human MOB1B / MOBKL1A
Human, Mouse
IHC - Paraffin, Western blot, ELISA
Unconjugated
Immunohistochemistry Image
Anti-MOB1B / MOBKL1A Antibody (C-Terminus, APC) LS-C245046
Rabbit Polyclonal (IgG) to Human MOB1B / MOBKL1A
Human
IHC, Western blot, ELISA
APC Conjugated
Anti-MOB1B / MOBKL1A Antibody (C-Terminus, PE) LS-C245049
Rabbit Polyclonal (IgG) to Human MOB1B / MOBKL1A
Human
IHC, Western blot, ELISA
PE Conjugated

100% Guaranteed 100% Guaranteed Publications Publications (2)
Rabbit Polyclonal to Human MOB1B / MOBKL1A
Human
IHC - Paraffin, Immunofluorescence, Western blot
Unconjugated

Details

Human MOB1B / MOBKL1A
Rabbit
Human (tested or 100% immunogen sequence identity)
Polyclonal
Unconjugated
Ammonium sulfate precipitation
Unmodified

Applications

  • IHC - Paraffin (1:10 - 1:50)
  • Immunofluorescence (1:10 - 1:50)
  • Western blot (1:1000)

Specificity and Use

MOB1B / MOBKL1A antibody was raised against kLH-conjugated synthetic peptide between amino acids 177-206 from C-terminal region of human MOB4A.
LS-E8625 - Lyophilized - 100 µg - $145.00
aa177-206

Packaging

PBS, 0.09% sodium azide
Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
For research use only.

Publications (2)

1
Epigenetic regulation of the alternatively activated macrophage phenotype. Ishii M, Wen H, Corsa CA, Liu T, Coelho AL, Allen RM, Carson WF, Cavassani KA, Li X, Lukacs NW, Hogaboam CM, Dou Y, Kunkel SL. Blood. 2009 114:3244-54. [PubMed:19567879] [PMC:PMC2759649]
2
Cancer susceptibility and embryonic lethality in Mob1a/1b double-mutant mice. Nishio M, Hamada K, Kawahara K, Sasaki M, Noguchi F, Chiba S, Mizuno K, Suzuki SO, Dong Y, Tokuda M, Morikawa T, Hikasa H, Eggenschwiler J, Yabuta N, Nojima H, Nakagawa K, Hata Y, Nishina H, Mimori K, Mori M, Sasaki T, Mak TW, Nakano T, Itami S, Suzuki A. The Journal of clinical investigation. 2012 122:4505-18. [PubMed:23143302] [PMC:PMC3533542]

About MOB1B / MOBKL1A

NP_775739.1

MOB1B Antibody, MOB kinase activator 1B Antibody, MOB4A Antibody, Mob1 homolog 1A Antibody, MOBKL1A Antibody, MATS2 Antibody, MOB1 Mps One Binder homolog B Antibody

Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ.

Immunohistochemistry

Immunohistochemistry
Formalin-fixed and paraffin-embedded human brain tissue reacted with MOB4A antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.

Immunofluorescence

Immunofluorescence
Fluorescent image of NIH/3T3 cell stained with MOB4A Antibody. NIH/3T3 cells were fixed with 4% PFA (20 min), permeabilized with Triton X-100 (0.1%, 10 min), then incubated with MOB4A primary antibody (1:25, 1 h at 37°C). For secondary antibody, Alexa Fluor 488 conjugated donkey anti-rabbit antibody (green) was used (1:400, 50 min at 37°C). Cytoplasmic actin was counterstained with Alexa Fluor 555 (red) conjugated Phalloidin (7units/ml, 1 h at 37°C). MOB4A immunoreactivity is localized to Cytoplasm significantly.

Western blot

Western blot
Western blot of lysates from K562, Daudi cell line (from left to right), using MOB4A Antibody. Antibody was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L (HRP) at 1:5000 dilution was used as the secondary antibody. Lysates at 35ug per lane.

Western blot

Western blot
MOB4A Antibody western blot of Daudi,K562 cell line lysates (35 ug/lane). The MOB4A antibody detected the MOB4A protein (arrow).

Requested From: United States
Date Requested: 12/3/2016

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