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MOAP1 / MAP1

modulator of apoptosis 1

Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in a variety of diseases such as cancer. Members of the Bcl-2 family are known to be critical regulators of this process. These proteins are characterized by the presence of several conserved motifs termed Bcl-2 homology (BH) domains. A related protein termed MAP-1 has recently been identified. This protein contains a BH3-like domain and induces caspase-dependent apoptosis in mammalian cells when overexpressed. It forms homodimers and associates with Bcl-2 family members such as Bax, Bcl-2, and Bcl-XL in vitro and in vivo. It has been suggested that MAP-1 associates with the tumor suppressor RASSF1A following death receptor activation, allowing a conformational change in Bax that leads to cellular apoptosis.

Gene Name: modulator of apoptosis 1
Family/Subfamily: Apoptosis
Synonyms: MOAP1, MAP-1, MAP1, Modulator of apoptosis 1, Paraneoplastic antigen like 4, Paraneoplastic antigen Ma4, PNMA4
Target Sequences: NM_022151 NP_071434.2 Q96BY2

Publications (1)

1
The RASSF1A tumor suppressor activates Bax via MOAP-1. Vos MD, Dallol A, Eckfeld K, Allen NP, Donninger H, Hesson LB, Calvisi D, Latif F, Clark GJ. The Journal of biological chemistry. 2006 281:4557-63. (WB) [PubMed:16344548]

☰ Filters
Antibodies (37)
Proteins (6)
Over-Expression Lysate (2)
Primary (37)
Recombinant (4)
MOAP1 / MAP1 (43)
Human (36)
Mouse (9)
Rat (3)
IHC (4)
IHC-Fr (1)
IHC-P (4)
WB (33)
ELISA (15)
rabbit (29)
mouse (8)
Product Group
IHCPlus (1)
IgG (22)
IgG1 (1)
IgG1,k (6)
monoclonal mc (7)
polyclonal pc (30)
AP Conjugated (1)
APC Conjugated (3)
Azide-free (1)
Biotin Conjugated (4)
FITC Conjugated (4)
HRP Conjugated (4)
PE Conjugated (3)
Unconjugated (18)
aa37-65 (7)
C-Terminus (4)
aa337-351 (3)
aa1-351 (1)
No (43)
GST (1)
GST, N-terminus (1)
His (1)
Myc-DDK (Flag) (3)
Human (5)
293T Cells (1)
E. coli (2)
HEK 293 Cells (2)
Wheat Germ Extract (1)
Purified (3)
MOAP1 / MAP1 Antibody - Anti-MOAP1 / MAP1 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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MOAP1 / MAP1 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, IHC, IHC-P, WB
Unconjugated
0.05 mg/$460
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MOAP1 / MAP1 Mouse anti-Rat Monoclonal Antibody
Rat
IHC, IHC-Fr, IHC-P, WB
Unconjugated
100 µg/$564
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MOAP1 / MAP1 Mouse anti-Human Monoclonal Antibody
Human
ELISA, WB
Unconjugated
100 µg/$705
Select
MOAP1 / MAP1 Mouse anti-Human Monoclonal (HRP) Antibody
Human
ELISA, WB
HRP Conjugated
100 µl/$904
Select
MOAP1 / MAP1 Mouse anti-Human Monoclonal (Biotin) Antibody
Human
ELISA, WB
Biotin Conjugated
100 µl/$904
Select
MOAP1 / MAP1 Mouse anti-Human Monoclonal (FITC) Antibody
Human
ELISA, WB
FITC Conjugated
100 µl/$904
Select
MOAP1 / MAP1 Mouse anti-Human Monoclonal (PE) Antibody
Human
ELISA, WB
PE Conjugated
100 µl/$904
Select
MOAP1 / MAP1 Mouse anti-Human Monoclonal (APC) Antibody
Human
ELISA, WB
APC Conjugated
100 µl/$904
Select
MOAP1 / MAP1 Rabbit anti-Human Polyclonal (aa37-65) Antibody
Human
ELISA, WB
Unconjugated
200 µl/$734
Select
MOAP1 / MAP1 Rabbit anti-Human Polyclonal (aa37-65) (Biotin) Antibody
Human
ELISA, WB
Biotin Conjugated
200 µl/$952
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MOAP1 / MAP1 Rabbit anti-Human Polyclonal (aa37-65) (FITC) Antibody
Human
ELISA, WB
FITC Conjugated
200 µl/$952
Select
MOAP1 / MAP1 Rabbit anti-Human Polyclonal (aa37-65) (APC) Antibody
Human
ELISA, WB
APC Conjugated
200 µl/$952
Select
MOAP1 / MAP1 Rabbit anti-Human Polyclonal (aa37-65) (PE) Antibody
Human
ELISA, WB
PE Conjugated
200 µl/$952
Select
MOAP1 / MAP1 Rabbit anti-Human Polyclonal (aa37-65) (Azide-free) (HRP) Antibody
Human
ELISA, WB
HRP Conjugated, Azide-free
200 µl/$952
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MOAP1 / MAP1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
100 µg/$357
MOAP1 / MAP1 Antibody - Immunohistochemistry of paraffin-embedded Rat kidney using MOAP1 Polyclonal Antibody at dilution of 1:100 (40x lens).
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MOAP1 / MAP1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
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MOAP1 / MAP1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
MOAP1 / MAP1 Antibody - Immunochemical staining of human MOAP1 in human brain with rabbit polyclonal antibody at 1:100 dilution, formalin-fixed paraffin embedded sections.
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MOAP1 / MAP1 Rabbit anti-Human Polyclonal Antibody
Human
IHC-P, WB
Unconjugated
100 µl/$412
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MOAP1 / MAP1 Rabbit anti-Human Polyclonal (aa1-351) Antibody
Human
ELISA
Unconjugated
50 µl/$294; 100 µl/$360
Select
MOAP1 / MAP1 Rabbit anti-Human Polyclonal (aa337-351) Antibody
Human
WB
Unconjugated
100 µg/$725
Select
MOAP1 / MAP1 Rabbit anti-Human Polyclonal (aa337-351) Antibody
Human
WB
Unconjugated
50 µg/$444; 100 µg/$597
Select
MOAP1 / MAP1 Rabbit anti-Human Polyclonal (aa337-351) Antibody
Human
WB
Unconjugated
100 µg/$475
Select
MOAP1 / MAP1 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
WB
Unconjugated
100 µg/$749
Select
MOAP1 / MAP1 Rabbit anti-Human Polyclonal Antibody
Human
WB
Unconjugated
100 µl/$412
MOAP1 / MAP1 Antibody - MOAP1 Antibody western blot of 293 cell line lysates (35 ug/lane). The MOAP1 antibody detected the MOAP1 protein (arrow).
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MOAP1 / MAP1 Rabbit anti-Human Polyclonal (aa37-65) Antibody
Human
WB
Unconjugated
400 µl/$393
Viewing 1-25 of 43 product results



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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).