Human MMP9 / Gelatinase B

Mouse

Human (tested or 100% immunogen sequence identity)

IgG1 Monoclonal

4A3

Unconjugated

Protein G purified

Unmodified

Ovalbumin conjugated synthetic peptide corresponding to a region within the N-Terminus of human MMP-9.

N-Terminus

Recognizes the active form of human matrix metalloproteinase 9 (MMP-9). The MMPs are zinc-dependent endopeptidases responsible for degrading the extracellular matrix. They are also involved in cell proliferation, migration, differentiation and apoptosis. Most MMPs are synthesized as inactive zymogens and a propeptide region must be cleaved off before the enzyme becomes active. Their expression is increased dramatically in a variety of cancer types, where it indicates invasive disease and a poor prognosis. MMP-9 is a gelatinase, cleaving type IV collagen and gelatin. The gelatinases have an additional gelatin-binding domain inserted in the catalytic domain. MMP-9, alongside other MMPs, plays a role in normal tissue remodeling such as embryonic development, ovulation, mammary gland involution and wound healing. It is important in the early stages of tumor invasion as it degrades the type IV collagen in the basement membrane. The antibody recognizes only the active form of MMP-9. It does not react with the MMP-9 proenzyme or the active or proenzyme forms of MMP-2.

• IHC - Paraffin (1:25 - 1:100)
• Western blot

PBS, 0.09% Sodium Azide

Store at 4°C or at -20°C. Store undiluted. Avoid freeze-thaw cycles. Microcentrifugation recommended if solution contains precipitate.

For research use only. Intended for use by laboratory professionals.

This antibody carries the LSBio 100% Guarantee.

Uniprot: P14780 NCBI: NM_004994 NP_004985.2