Human MMP7 / Matrilysin

Rabbit

Human (tested or 100% immunogen sequence identity)

IgG Polyclonal

Unconjugated

Immunoaffinity purified

Unmodified

Human partial recombinant protein (aa1-267).

aa1-267

Human MMP7 / Matrilysin

• IHC
• IHC - Paraffin (0.5 - 1 µg/ml)
• Western blot (0.5 - 1 µg/ml)
• ELISA (0.1 - 0.5 µg/ml)

Matrix metalloproteinase-7, previously called putative metalloproteinase I (PUMP1) or Matrilysin, has been identified through studies of collagenase-related connective-tissue-degrading metalloproteinases produced by human tumors. The protein has 267 amino acids and is significantly shorter than stromelysin or collagenase (477 and 469 amino acids, respectively). Matrix metalloproteinases play a crucial role in tumor invasion and metastasis. MMP7, a member of the matrix metalloproteinase family, is structurally different from the other matrix metalloproteinases by virtue of the absence of a conserved COOH-terminal protein domain. In addition, mRNA is regulated in a specific and distinct manner in normal and malignant tissues. MMP7 has been shown to correlate with nodal or distant metastasis in colorectal carcinomas, however, its implication in early invasive colorectal carcinomas has not been determined. It is a mediator of pulmonary fibrosis and a potential therapeutic target.

Lyophilized from PBS, 2.5% BSA, 0.025% sodium azide.

Reconstitute in sterile distilled water.

Prior to reconstitution, 4°C. Following reconstitution store at -20°C. Avoid freeze-thaw cycles.

For research use only. Intended for use by laboratory professionals.

This antibody carries the LSBio 100% Guarantee.

Uniprot: P09237 NCBI: NM_002423 NP_002414.1