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Anti-MMP2 Antibody LS-C8718

Ordering

Wt. Vol. Conc. Price
100 µg - - $605
Inquire for larger quantities

LSBio (Direct) LSBio (Direct)
206-374-1102
866-206-6909
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Mouse Monoclonal (IgG1) to Human MMP2
Human
IHC, Immunofluorescence, Western blot, Immunoprecipitation
Unconjugated

Details

Human MMP2
Mouse
Human (tested or 100% immunogen sequence identity)
IgG1 Monoclonal
Protein G purified

Applications

IHC, Immunofluorescence, Western blot (1 - 2 µg/ml), Immunoprecipitation

Specificity and Use

MMP2 antibody was raised against human native Gelatinase A, 72kD.
Recognizes proteins of 72kD and 66kD which are identified as pro (latent) and active forms of matrix metalloproteinase-2 (MMP-2; also known as 72kD collagenase IV or gelatinase A). Shows no cross-reactivity with pro and active forms of other MMPs. Recognizes human.
Western blot: 1-2 ug/ml for 2 hours at RT. Immunofluorescence. Immunoprecipitation on native protein: 2 ug/mg of protein lysate. Not suitable for immunohistochemistry. Positive control: Conditioned, serum-free medium from (TPA-treated) HFL-1 cells.

Packaging

10 mM PBS, pH 7.4, 0.2% BSA, 0.09% sodium azide.
Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.
For research use only.

About MMP2

P08253 NM_004530 NP_004521.1

MMP2 Antibody, 72 kd type iv collagenase Antibody, 72 kDa gelatinase Antibody, 72 kd gelatinase Antibody, 72 kDa type IV collagenase Antibody, CLG4A Antibody, CLG4 Antibody, GelA Antibody, Gelatinase A Antibody, Matrix metalloproteinase-2 Antibody, MMP-2 Antibody, MONA Antibody, Neutrophil gelatinase Antibody, TBE-1 Antibody, Tbe-1 metalloprotease Antibody, Collagenase type IV-A Antibody, Matrix metalloproteinase-II Antibody, MMP-II Antibody

Ubiquitinous metalloproteinase that is involved in diverse functions such as remodeling of the vasculature, angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture. As well as degrading extracellular matrix proteins, can also act on several nonmatrix proteins such as big endothelial 1 and beta-type CGRP promoting vasoconstriction. Also cleaves KISS at a Gly-|-Leu bond. Appears to have a role in myocardial cell death pathways.

Requested From: United States
Date Requested: 9/27/2016

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