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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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MMP2 Antibody (APMA‑Activated) LS‑C8720
MMP2 antibody LS-C8720 is an unconjugated mouse monoclonal antibody to human MMP2. Validated for IHC.
Antibody
Catalog
Size
Price
LS-C8720-500
500 µl
$785

Popular MMP2 Products

Anti-MMP2 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B2641 concentration 10 ug/ml.
Species: Human, Pig
Applications: IHC, IHC - Paraffin, IHC - Frozen, Western blot, ELISA
Anti-MMP2 antibody IHC of human skeletal muscle. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B2799 concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Species: Human, Mouse, Rat, Guinea pig, Chicken
Applications: IHC, IHC - Paraffin, IHC - Frozen, Western blot
Antibody
Species: Human
Applications: IHC, IHC - Paraffin, IHC - Frozen, Western blot, Immunoprecipitation, ELISA
Antibody
Species: Human
Applications: IHC, IHC - Paraffin, IHC - Frozen, ELISA
Antibody
Species: Human, Mouse, Rat, Bat, Bovine, Dog, Hamster, Pig, Sheep, Chicken, Xenopus, Zebrafish
Applications: Western blot

Product Description

MMP2 antibody LS-C8720 is an unconjugated mouse monoclonal antibody to human MMP2. Validated for IHC.
About MMP2
Ubiquitinous metalloproteinase that is involved in diverse functions such as remodeling of the vasculature, angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture. As well as degrading extracellular matrix proteins, can also act on several nonmatrix proteins such as big endothelial 1 and beta-type CGRP promoting vasoconstriction. Also cleaves KISS at a Gly-|-Leu bond. Appears to have a role in myocardial cell death pathways. P08253 NM_004530 NP_004521.1

MMP2 Antibody, 72 kd type iv collagenase Antibody, 72 kDa gelatinase Antibody, 72 kd gelatinase Antibody, 72 kDa type IV collagenase Antibody, CLG4A Antibody, CLG4 Antibody, GelA Antibody, Gelatinase A Antibody, Matrix metalloproteinase-2 Antibody, MMP-2 Antibody, MONA Antibody, Neutrophil gelatinase Antibody, TBE-1 Antibody, Tbe-1 metalloprotease Antibody, Collagenase type IV-A Antibody, Matrix metalloproteinase-II Antibody, MMP-II Antibody


Specifications

Target
Human MMP2
Host
Mouse
Reactivity
Human (tested or 100% immunogen sequence identity)
Clonality
IgG1 Monoclonal
Conjugations
Unconjugated
Purification
Protein G purified
Modifications
Unmodified
Applications
  • IHC
  • IHC - Paraffin (2 - 4 µg/ml)
  • IHC - Frozen (2 - 4 µg/ml)
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Immunogen
MMP2 antibody was raised against human APMA-activated native 72kD Gelatinase A.
Epitope
APMA-Activated
Specificity
Recognizes proteins of 72kD and ~66kD which are identified as pro (latent) and active forms of matrix metalloproteinase-2 (MMP-2; also known as 72kD collagenase IV or gelatinase A). No cross-reaction with pro and active forms of other MMPs.
Usage
Immunohistochemistry (Frozen & fixed-paraffin embedded) 2-4 ug/ml g/ml 30 min at RT. Staining of formalin-fixed tissues is improved by boiling tissue sections in 10 mM citrate buffer, pH6.0, for 10-20 min followed by cooling at RT for 20 min. Positive control: Conditioned, serum-free medium from (dexamethasone-treated) human fibrosarcoma HT-1080 or endothelial HUVEC cells. Placenta, bladder, breast and ovarian carcinomas. S.
Presentation
10 mM PBS, pH 7.4, 15 mM Sodium Azide, 0.2% BSA
Storage
Short term: 4°C. Long term: Store at -20°C. Avoid freeze-thaw cycles.
Restrictions
For research use only.

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Requested From: United States
Date Requested: 9/24/2018

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