MMP2

matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)

Ubiquitinous metalloproteinase that is involved in diverse functions such as remodeling of the vasculature, angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture. As well as degrading extracellular matrix proteins, can also act on several nonmatrix proteins such as big endothelial 1 and beta-type CGRP promoting vasoconstriction. Also cleaves KISS at a Gly-|-Leu bond. Appears to have a role in myocardial cell death pathways. Contributes to myocardial oxidative stress by regulating the activity of GSK3beta. Cleaves GSK3beta in vitro. Involved in the formation of the fibrovascular tissues in association with MMP14.PEX, the C-terminal non-catalytic fragment of MMP2, posseses anti-angiogenic and anti-tumor properties and inhibits cell migration and cell adhesion to FGF2 and vitronectin. Ligand for integrinv/beta3 on the surface of blood vessels.Isoform 2: Mediates the proteolysis of CHUK/IKKA and initiates a primary innate immune response by inducing mitochondrial-nuclear stress signaling with activation of the pro-inflammatory NF-kappaB, NFAT and IRF transcriptional pathways.

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Products

Antibodies (145)

ELISA Kits (52)

Proteins (22)

Type

Cell-Based (1)

Competitive EIA (2)

Custom (3)

Over-Expression Lysate (2)

Primary (145)

Recombinant (20)

Sandwich (39)

Sandwich CLIA (7)

Target

MMP2 (219)

Reactivity

Human (135)

Mouse (55)

Rat (63)

Bovine (4)

Canine (1)

Cat (1)

Chicken (2)

Dog (5)

Gibbon (3)

Guinea pig (4)

Horse (6)

Monkey (7)

Pig (17)

Primate (1)

Rabbit (4)

Sheep (3)

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Application

IHC (52)

IHC-Fr (13)

IHC-P (14)

WB (115)

ELISA (45)

ICC (2)

IF (9)

IP (22)

Peptide-ELISA (2)

Host

rabbit (87)

mouse (58)

Product Group

IHCPlus (3)

PathPlus Neuro (1)

Isotype

IgG (48)

IgG1 (24)

IgG1,k (25)

IgG2a (4)

IgG2b,k (1)

Clonality

monoclonal mc (58)

polyclonal pc (87)

Clone

1H1 (1)

2C1 (1)

42-5D11 (1)

4D1E2 (2)

4D3 (2)

MMP2/1501 (2)

MMP2/2C1 (5)

OTI4A11 (2)

OTI4B11 (2)

SB13a (2)

Format

12 x 8-Well Microstrips (2)

96-Well Microplate (12)

96-Well Strip Plate (38)

APC (4)

APC Conjugated (10)

Azide-free (1)

Biotin Conjugated (14)

BSA-free (1)

Carrier-free (2)

Concentrated (1)

Cy3 Conjugated (4)

Cy7 Conjugated (4)

DY488 Conjugated (1)

DY550 Conjugated (1)

DY650 Conjugated (1)

FITC Conjugated (13)

HRP Conjugated (14)

PE Conjugated (10)

Unconjugated (73)

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Epitope

aa110-660 (8)

aa445-660 (8)

aa303-331 (7)

C-Terminus (5)

aa110-662 (4)

aa228-507 (4)

APMA-Activated (2)

aa468-483 (2)

580-660 aa, C-terminal (1)

Amino Acid: 242-396 (1)

Leu638 (1)

aa193-575 (1)

aa550-600 (1)

aa611-660 (1)

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Publications

No (219)

Sample Type

Adherent Cell Cultures (1)

Cell Culture Supernatants (16)

Cell Lysates (4)

Plasma (46)

Serum (46)

Tissue Homogenates (20)

Tag

6His, C-terminus (2)

6His, N-terminus (1)

GST (1)

GST, N-terminus (1)

His (3)

His, N-Terminal (4)

His-SUMO (1)

Myc-DDK (Flag) (3)

Species

Human (16)

Mouse (2)

Rat (3)

Source

293T Cells (1)

E. coli (10)

HEK 293 Cells (4)

Human Cells (2)

Mammalian Cells (1)

Wheat Germ Extract (2)

Yeast (1)

Purification

Purified (6)

Low Endotoxin Level

Low endotoxin level (7)

Biologically Active

Biologically active (2)

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PathPlus™ MMP2 Antibody (aa468-483) LS-B2641

Neuroscience

(5.0) Rating

Antibody:

MMP2 Mouse anti-Human Monoclonal (aa468-483) Antibody

Reactivity:

Pig, Human

Applications:

ELISA, IHC, IHC-Fr, IHC-P, WB

Format:

Unconjugated

Price:

50 µg/$485

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MMP2 Antibody (C-Terminus) LS-C352523

Antibody:

MMP2 Rabbit anti-Human Polyclonal (C-Terminus) Antibody

Reactivity:

Mouse, Dog, Bovine, Rat, Pig, Human

Applications:

ICC, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$299

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MMP2 Antibody (clone SB13a) LS-C149696

Antibody:

MMP2 Mouse anti-Human Monoclonal (SB13a) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-Fr, IHC-P

Format:

Unconjugated

Price:

0.1 mg/$383

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MMP2 Antibody (clone 4D3) LS-C27029

Antibody:

MMP2 Mouse anti-Human Monoclonal (4D3) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

200 µg/$454

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MMP2 Antibody (clone 4D1E2) LS-C169152

Antibody:

MMP2 Mouse anti-Human Monoclonal (4D1E2) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µl/$459

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MMP2 Antibody (C-Terminus) LS-C31756

Antibody:

MMP2 Rabbit anti-Human Polyclonal (C-Terminus) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$397

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MMP2 Antibody LS-C746891

Antibody:

MMP2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, IHC, WB

Format:

Unconjugated

Price:

20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503

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MMP2 Antibody LS-C8714

Antibody:

MMP2 Mouse anti-Human Monoclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-Fr, IHC-P, IP, WB

Format:

Unconjugated

Price:

100 µg/$786

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Rat MMP2 (Sandwich ELISA) ELISA Kit - LS-F24966

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rat

Range:

156 - 10000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Plasma, Serum

Price:

1 Plate/$717

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Human MMP2 (Sandwich ELISA) ELISA Kit - LS-F2512

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Human

Range:

625 - 40000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Plasma, Serum

Price:

1 Plate/$795

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Pig MMP2 (Sandwich ELISA) ELISA Kit - LS-F7320

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Pig

Range:

31.2 - 2000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Lysates, Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$889

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MMP2 Antibody (clone MMP2/2C1) LS-C2814

Antibody:

MMP2 Mouse anti-Human Monoclonal (MMP2/2C1) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IHC, IHC-Fr, IP, WB

Format:

Unconjugated

Price:

0.1 ml/$386

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MMP2 Antibody LS-C417149

Antibody:

MMP2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

WB

Format:

Unconjugated

Price:

50 µg/$305; 100 µg/$357

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Human MMP2 Protein (Recombinant) - LS-G437

Source:

E. coli

Tag:

None

Biological Activity:

Biologically active

Endotoxin Level:

Less than 0.1 ng/µg of protein (less than 1EU/µg).

Molecular Weight:

62.0 kDa

Price:

2 µg/$268; 10 µg/$349

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MMP2 Antibody LS-C314391

Antibody:

MMP2 Rabbit anti-Pig Polyclonal Antibody

Reactivity:

Pig

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$317; 200 µl/$362; 500 µl/$513; 1 ml/$589

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MMP2 Antibody (580-660 aa, C-terminal) LS-C384612

Antibody:

MMP2 Rabbit anti-Human Polyclonal (580-660 aa, C-terminal) Antibody

Reactivity:

Mouse, Rat, Human, Monkey

Applications:

ELISA, IF, IHC, WB

Format:

Unconjugated

Price:

50 µg/$295; 100 µg/$335; 200 µg/$394

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MMP2 Antibody LS-C72181

Antibody:

MMP2 Mouse anti-Human Monoclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IHC, IHC-Fr, IHC-P, IP, WB

Format:

Unconjugated

Price:

100 µl/$668

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Mouse MMP2 (Sandwich ELISA) ELISA Kit - LS-F21409

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Mouse

Range:

0.16 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$626

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Human MMP2 (Sandwich ELISA) ELISA Kit - LS-F24619

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

312.5 - 20000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$669

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MMP2 Antibody (APMA-Activated) LS-C8720

Antibody:

MMP2 Mouse anti-Human Monoclonal (APMA-Activated) Antibody

Reactivity:

Human

Applications:

IHC, IHC-Fr, IHC-P

Format:

Unconjugated

Price:

500 µl/$1,039

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MMP2 Antibody LS-C137287

Antibody:

MMP2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

IHC, WB

Format:

Unconjugated

Price:

100 µl/$332

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IHC-plus™ MMP2 Antibody LS-B15998

(4.0) Rating

Antibody:

MMP2 Rabbit anti-Mouse Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC

Format:

Unconjugated

Price:

60 µl/$460

Select

MMP2 Antibody LS-C8716

Antibody:

MMP2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

IP, WB

Format:

Unconjugated

Price:

500 µl/$543

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MMP2 Antibody (aa611-660) LS-C118525

Antibody:

MMP2 Rabbit anti-Human Polyclonal (aa611-660) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

Peptide-ELISA, WB

Format:

Unconjugated

Price:

50 µl/$334; 100 µl/$397

Select

MMP2 Antibody (APMA-Activated) LS-C8735

Antibody:

MMP2 Mouse anti-Human Monoclonal (APMA-Activated) Antibody

Reactivity:

Human

Applications:

ELISA

Format:

Unconjugated

Price:

500 µl/$961

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