The Immunohistochemistry Antibody Company
|Human (tested or 100% immunogen sequence identity)|
|IHC, Western blot, ELISA|
|Specifically binds to MMP19 and does not cross-react with the other MMP family members (MMP1, MMP2, MMP3, MMP9, etc). The zymogen of MMP19 is found at 58kD and is activated to a 55kD form, a 45-47kD form, and then to a 28kD final active form. Depending on the activation method, MMP19 can be seen as a cascade of active forms. Recognizes the pro-form and active forms of MMP19. By immunoblotting against the reduced protein, the antibody reacts with bands at 58kD (zymogen), 45kD (active), and a series of further cleaved active forms. The antibody also recognizes nonreduced MMP19. Species cross-reactivity: Cross-reacts with Human.|
|Suitable for use in ELISA, Western Blot and Immunohistochemistry. Positive control: Human fibroblasts.|
|Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.|
|For research use only.|
MMP19 Antibody, Matrix metalloproteinase 19 Antibody, Matrix metalloproteinase RASI Antibody, MMP-19 Antibody, MMP-18 Antibody, RASI Antibody, Matrix metallopeptidase 19 Antibody, Matrix metalloproteinase-18 Antibody, RASI-1 Antibody, Matrix metalloproteinase 18 Antibody, Matrix metalloproteinase-19 Antibody, MMP18 AntibodyEndopeptidase that degrades various components of the extracellular matrix, such as aggrecan and cartilage oligomeric matrix protein (comp), during development, haemostasis and pathological conditions (arthritic disease). May also play a role in neovascularization or angiogenesis. Hydrolyzes collagen type IV, laminin, nidogen, nascin-C isoform, fibronectin, and type I gelatin.