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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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MMP16 Antibody (aa168‑181) LS‑C16429
MMP16 antibody LS-C16429 is an unconjugated mouse monoclonal antibody to MMP16 from human, mouse, rat and other species. Validated for IHC and WB.
Antibody
Catalog
Size
Price
LS-C16429-100
100 µg (2 mg/ml)
$650

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Applications: IHC, IHC - Paraffin, IHC - Frozen, Western blot

Product Description

MMP16 antibody LS-C16429 is an unconjugated mouse monoclonal antibody to MMP16 from human, mouse, rat and other species. Validated for IHC and WB.

Specifications

Target
Human MMP16
Synonyms
MMP16, C8orf57, MMP-X2, MT-MMP3, MT3MMP, MT-MMP 3, MT-MMP2, MT2-MMP, Matrix metalloproteinase-16, Membrane type 3-MMP, MMP-16, MMPX2, MT3-MMP, MTMMP3
Host
Mouse
Reactivity
Human, Monkey, Mouse, Rat, Bat, Bovine, Dog, Hamster, Pig (tested or 100% immunogen sequence identity)
Predicted
Horse, Chicken, Xenopus (at least 90% immunogen sequence identity)
Clonality
IgG1,k Monoclonal
Conjugations
Unconjugated. Also available conjugated with AP, APC, Biotin, FITC, HRP, PE.
Purification
Purified
Modifications
Unmodified
Applications
  • IHC
  • IHC - Paraffin
  • Western blot (10 µg/ml)
  • (applications tested for the base form of this product only)
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Immunogen
MMP16 antibody was raised against oligopeptide EEVPYSELENGKRD (aa168-181) on human membrane-type 3 matrix metalloproteinase (human MT3- MMP). Percent identity by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset, Mouse, Rat, Hamster, Elephant, Panda, Bovine, Dog, Bat, Pig, Opossum, Platypus (100%); Horse, Turkey, Chicken, Lizard, Xenopus (93%).
Epitope
aa168-181
Specificity
Recognizes human MT3-MMP. Does not cross-react with human MT1 or MT2-MMPs.
Usage
Suitable for use in Western Blot and Immunohistochemistry. Western Blot: 10 ug/ml. Recognizes a band of ~60kD. Immunohistochemistry: 10 ug/ml paraffin embedded tissue.
Presentation
0.1 M sodium phosphate buffer, pH 7.0, 2% BSA (protease free).
Storage
May be stored at 4°C for short-term only. Aliquot to avoid freeze-thaw cycles. Store at -20°C. Aliquots are stable for up to 1 year.
Restrictions
For research use only.
About MMP16
MMP16 is an endopeptidase that degrades various components of the extracellular matrix, such as collagen type III and fibronectin. Activates progelatinase A. Involved in the matrix remodeling of blood vessels. Isoform short cleaves fibronectin and also collagen type III, but at lower rate. It has no effect on type I, II, IV and V collagen. However, upon interaction with CSPG4, it may be involved in degradation and invasion of type I collagen by melanoma cells. P51512 NM_005941 NP_005932.2


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Requested From: United States
Date Requested: 11/13/2018

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