The Immunohistochemistry Antibody Company
|Human (tested or 100% immunogen sequence identity)|
|MMP15 antibody was raised against a synthetic peptide from the second quarter of human MMP-15/MT2-MMP.|
|Reacts with a 66 kD (latent) and 54 kD (active) proteins. MMPs are a group of enzymes involved in matrix degradation. Of the sixteen members of matrix metalloproteinase family ten exist in soluble form whereas MT-MMPs exist as integral membrane proteins. MT1-MMP, MT2-MMP and MT3-MMP also known as MMp14, MMP15 and MMp16 respectively. They contain a C-terminal transmembrane domain anchoring them to the cell surface. MT2-MMP plays a minor role in activation of pro-MMP2 to its active form in breast carcinomas. Coexpression of MT1-MMP and MT2-MMP in advanced stages of breast carcinomas is indicative of possible involvement of MT2-MMP in its metastasis.|
|0.05% sodium azide|
|Store at 2°C to 8°C degrees. Do not freeze.|
|For research use only.|
MMP15 Antibody, MT2-MMP Antibody, MT2MMP Antibody, MTMMP2 Antibody, MMP-15 Antibody, MT-MMP 2 Antibody, Matrix metalloproteinase-15 Antibody, SMCP-2 AntibodyProteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases.