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Anti-MMP13 Antibody IHC-plus™ LS-B3168

Note: This antibody replaces LS-C48499
Catalog Size Price
LS-B3168-50 50 µg (0.5 mg/ml) Unavailable

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131 MMP13 Antibodies

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Anti-MMP13 Antibody IHC-plus™ LS-B1232
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Immunohistochemistry Image
Anti-MMP13 Antibody (N-Terminus) IHC-plus™ LS-A1552
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Anti-MMP13 Antibody (Internal) IHC-plus™ LS-A1553
Rabbit Polyclonal to Human MMP13
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Anti-MMP13 Antibody (C-Terminus) IHC-plus™ LS-A1554
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Anti-MMP13 Antibody IHC-plus™ LS-B3168
Rabbit Polyclonal to Rat MMP13
Rat, Human, Mouse, Bovine, Horse, Rabbit
IHC - Paraffin, Western blot, Immunoprecipitation
Unconjugated
Immunohistochemistry Image

100% Guaranteed Publications (1)
Rabbit Polyclonal to Rat MMP13
Rat, Human, Mouse, Bovine, Horse, Rabbit
IHC - Paraffin, Western blot, Immunoprecipitation
Unconjugated

Details

Rat MMP13
Rabbit
Rat, Human, Mouse, Bovine, Horse, Rabbit (tested or 100% immunogen sequence identity)
Polyclonal
Unconjugated
Immunoaffinity purified
Unmodified

Applications

  • IHC - Paraffin (5 µg/ml)
  • Western blot (0.5 - 4 µg/ml)
  • Immunoprecipitation

Specificity and Use

MMP13 antibody was raised against synthetic peptide surrounding amino acid 454 of rat MMP-13
The antibody recognizes the proenzyme (~60 kDa) and the cleaved fragments (34 kDa and 48kDa) of MMP-13.
Immunohistochemistry: LS-B3168 was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen. The stained slides were evaluated by a pathologist to confirm staining specificity. The optimal working concentration for LS-B3168 was determined to be 5 ug/ml.

Packaging

PBS, 30% glycerol, 0.5% BSA, 0.01 % Thimerosal.
Long term: -70°C; Short term: -20°C; Avoid freeze-thaw cycles.
For research use only.

Publications (1)

1
Comparison of gait and pathology outcomes of three meniscal procedures for induction of knee osteoarthritis in sheep. Cake MA, Read RA, Corfield G, Daniel A, Burkhardt D, Smith MM, Little CB. Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society. 2013 21:226-36. (IHC; Sheep) [PubMed:23069853]

About MMP13

P45452 NM_002427 NP_002418.1

MMP13 Antibody, Collagenase 3 Antibody, Matrix metalloproteinase-13 Antibody, Interstitial collagenase Antibody, MANDP1 Antibody, MMP-13 Antibody, CLG3 Antibody

Plays a role in the degradation of extracellular matrix proteins including fibrillar collagen, fibronectin, TNC and ACAN. Cleaves triple helical collagens, including type I, type II and type III collagen, but has the highest activity with soluble type II collagen. Can also degrade collagen type IV, type XIV and type X. May also function by activating or degrading key regulatory proteins, such as TGFB1 and CTGF.

Immunohistochemistry

Immunohistochemistry
Anti-MMP13 antibody IHC of human uterus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B3168 concentration 5 ug/ml.

Immunohistochemistry

Immunohistochemistry
Anti-MMP13 antibody IHC of human bronchiole. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B3168 concentration 5 ug/ml.

Western blot

Western blot
Western blot of MMP-13 expression with Jurkat cell lysate

Requested From: 
Date Requested: 8/20/2017

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