Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
(applications tested for the base form of this product only)
Specificity and Use
MLXIPL / CHREBP antibody was raised against an internal synthetic peptide made to the human ChREBP protein sequence (between residues 50-150). [NCBI# NP_116569.1, isoform 1/alpha]. Percent identity by BLAST analysis: Mouse, Rat (83%).
The applications listed have been tested for the unconjugated form of this product. Other forms have not been tested.
MLXIPL / CHREBP is a basic helix-loop-helix leucine zipper transcription factor of the Myc/Max/Mad superfamily. This protein forms a heterodimeric complex and binds and activates, in a glucose-dependent manner, carbohydrate response element (ChoRE) motifs in the promoters of triglyceride synthesis genes. The gene is deleted in Williams-Beuren syndrome, a multisystem developmental disorder caused by the deletion of contiguous genes at chromosome 7q11.23.
Anti-MLXIPL / CHREBP antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B254 concentration 5 ug/ml. This image was taken for the unconjugated form of this product. Other forms have not been tested.
Immunofluorescent staining of a human hepatocyte. Overlay staining of ChREBP (Rhodamine red) and DAPI nuclear staining (blue). This image was taken for the unconjugated form of this product. Other forms have not been tested.
Requested From: United States
Date Requested: 3/1/2017