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Anti-MLH1 Antibody (clone G168-15) LS-C95607

Ordering

Wt. Vol. Conc. Price
- 0.5 ml - $385
- 1 ml - $545
Inquire for larger quantities

LSBio (Direct) LSBio (Direct)
206-374-1102
866-206-6909
Orders@LSBio.com
 

Most Popular MLH1 Antibodies

Anti-MLH1 Antibody IHC-plus™ LS-B3475
Mouse Monoclonal (IgG1) to Human MLH1
Human, Monkey
IHC - Paraffin, Immunofluorescence, Western blot, ELISA
Unconjugated
Immunohistochemistry Image
Anti-MLH1 Antibody (clone M1) LS-C133324
Mouse Monoclonal [clone M1] (IgG) to Human MLH1
Human
Immunofluorescence, Western blot, ELISA
Unconjugated
Immunofluorescence Image

100% Guaranteed 100% Guaranteed
Mouse Monoclonal [clone G168-15] (IgG1)
Human, Rat, Hamster
IHC - Paraffin
Unconjugated

Details

MLH1
Mouse
Human, Rat, Hamster (tested or 100% immunogen sequence identity)
IgG1 Monoclonal [G168-15]
Unconjugated
Unmodified

Applications

IHC - Paraffin

Specificity and Use

MLH1 antibody was raised against full length recombinant MLH.
The G168-15 antibody recognizes the human and mouse MLH1 (80-85kDa. The repair of mismatch DNA is essential to maintaining the integrity of genetic information over time. An alteration of microsatellite repeats is the result of slippage owing to strand misalignment during DNA replication and is referred to as microsatellite instability (MSI). These defects in DNA repair pathways have been related to human carcinogenesis. The importance of mismatch repair genes became apparent with the identification of the genetic basis for hereditary nonpolyposis colon cancer (HNPC). MSH-2 is involved in the initial cognition of mismatch nucleotides during the replication mismatch repair process. It is thought that after MSH2 binds to a mismatched DNA duplex it is joined by a heterodimer of MLH1 and PMSH, which together help facilitate the later steps in mismatch repair. cross reacts with human, hamster and rat

Packaging

Supplied as a liquid containing sodium azide as a preservative
Store at 2°C to 8°C degrees. Do not freeze.
For research use only.

About MLH1

P40692 NM_000249 NP_000240.1

MLH1 Antibody, COCA2 Antibody, FCC2 Antibody, HMLH1 Antibody, HNPCC Antibody, HNPCC2 Antibody, MutL protein homolog 1 Antibody

Heterodimerizes with PMS2 to form MutL alpha, a component of the post-replicative DNA mismatch repair system (MMR). DNA repair is initiated by MutS alpha (MSH2-MSH6) or MutS beta (MSH2-MSH6) binding to a dsDNA mismatch, then MutL alpha is recruited to the heteroduplex. Assembly of the MutL-MutS-heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of PMS2.

Requested From: United States
Date Requested: 12/7/2016

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