MLH1

mutL homolog 1

Heterodimerizes with PMS2 to form MutL alpha, a component of the post-replicative DNA mismatch repair system (MMR). DNA repair is initiated by MutS alpha (MSH2-MSH6) or MutS beta (MSH2-MSH6) binding to a dsDNA mismatch, then MutL alpha is recruited to the heteroduplex. Assembly of the MutL-MutS-heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of PMS2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to degrade the strand containing the mismatch. DNA methylation would prevent cleavage and therefore assure that only the newly mutated DNA strand is going to be corrected. MutL alpha (MLH1-PMS2) interacts physically with the clamp loader subunits of DNA polymerase III, suggesting that it may play a role to recruit the DNA polymerase III to the site of the MMR. Also implicated in DNA damage signaling, a process which induces cell cycle arrest and can lead to apoptosis in case of major DNA damages. Heterodimerizes with MLH3 to form MutL gamma which plays a role in meiosis.

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Products

Antibodies (76)

Proteins (5)

ELISA Kits (1)

Type

Over-Expression Lysate (2)

Primary (76)

Recombinant (3)

Sandwich (1)

Target

MLH1 (82)

Reactivity

Human (75)

Mouse (14)

Rat (13)

Bat (3)

Chimpanzee (3)

Dog (3)

Gibbon (3)

Guinea pig (3)

Hamster (4)

Horse (3)

Monkey (5)

Non-Human Primate (1)

Pig (3)

Rabbit (3)

Xenopus (3)

Zebrafish (3)

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Application

IHC (24)

IHC-Fr (3)

IHC-P (9)

WB (61)

Flo (8)

ELISA (23)

ICC (5)

IF (12)

IP (3)

Peptide-ELISA (1)

Host

rabbit (32)

mouse (44)

Product Group

IHCPlus (1)

Isotype

Ig (1)

IgG (24)

IgG1 (26)

IgG1,k (1)

IgG2a (4)

IgG2a,k (2)

IgG2b (5)

Clonality

monoclonal mc (45)

polyclonal pc (30)

recombinant monoclonal rmc (1)

Clone

164C819 (1)

4C9C7 (2)

ABT-MLH1 (1)

G168-15 (1)

G168-728 (3)

G409.1 (1)

M1 (1)

OTI10F9 (1)

OTI1B9 (2)

OTI1C1 (2)

OTI2A8 (1)

OTI2D12 (2)

OTI3C1 (2)

OTI3D1 (2)

OTI4B5 (1)

OTI4H6 (2)

OTI5A7 (2)

OTI5F3 (2)

OTI5H2 (1)

OTI6E8 (1)

OTI6F1 (2)

UMAB191 (2)

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Format

96-Well Strip Plate (1)

APC Conjugated (1)

Azide-free (1)

Biotin Conjugated (3)

Carrier-free (10)

Concentrated (1)

FITC Conjugated (3)

HRP Conjugated (3)

PE Conjugated (1)

Ready-to-Use (2)

Unconjugated (65)

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Epitope

aa299-527 (20)

aa452-480 (7)

aa1-298 (5)

aa35-84 (4)

410-490 aa, Internal (1)

Amino Acid: 381-483 (1)

C-Terminus (1)

Internal (1)

Ser467 (1)

aa387-403 (1)

aa441-490 (1)

aa458-489 (1)

aa557-756 (1)

aa700-C-term (1)

aa722-756 (1)

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Publications

No (82)

Sample Type

Cell Lysates (1)

Tissue Homogenates (1)

Tag

GST (1)

GST, N-terminus (1)

Myc-DDK (Flag) (3)

Species

Human (4)

Source

293T Cells (1)

HEK 293 Cells (2)

Wheat Germ Extract (2)

Purification

Purified (1)

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IHC-plus™ MLH1 Antibody (clone 4C9C7) LS-B3475

(4.0) Rating

Antibody:

MLH1 Mouse anti-Human Monoclonal (4C9C7) Antibody

Reactivity:

Human

Applications:

ELISA, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µl/$440

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MLH1 Antibody (clone M1) LS-C133324

Antibody:

MLH1 Mouse anti-Human Monoclonal (M1) Antibody

Reactivity:

Human

Applications:

ELISA, IF, WB

Format:

Unconjugated

Price:

100 µg/$423

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Human MLH1 (Sandwich ELISA) ELISA Kit - LS-F8678

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Lysates, Tissue Homogenates

Price:

1 Plate/$834

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MLH1 Antibody (clone G168-728) LS-C312102

Antibody:

MLH1 Mouse anti-Human Monoclonal (G168-728) Antibody

Reactivity:

Human

Applications:

IHC, IHC-Fr, IHC-P

Format:

Unconjugated

Price:

0.1 ml/$340

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MLH1 Antibody (clone G168-728, Ready-to-Use) LS-C348524

Antibody:

MLH1 Mouse anti-Human Monoclonal (Ready-to-Use) (G168-728) Antibody

Reactivity:

Human

Applications:

IHC-Fr, IHC-P

Format:

Unconjugated, Ready-to-Use

Price:

3 ml/$316

• Unconjugated
• Unconjugated, Ready-to-Use

• Unconjugated
• Unconjugated, Ready-to-Use

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MLH1 Antibody LS-C109333

Antibody:

MLH1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ICC, IF, WB

Format:

Unconjugated

Price:

100 µl/$450

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MLH1 Antibody (410-490 aa, Internal) LS-C384568

Antibody:

MLH1 Rabbit anti-Human Polyclonal (410-490 aa, Internal) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IF, WB

Format:

Unconjugated

Price:

50 µg/$295; 100 µg/$335; 200 µg/$394

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MLH1 Antibody (clone G168-15) LS-C95607

Antibody:

MLH1 Mouse Monoclonal (G168-15) Antibody

Reactivity:

Rat, Hamster, Human

Applications:

IHC, IHC-P

Format:

Unconjugated

Price:

0.1 ml/$283; 0.5 ml/$497; 1 ml/$729

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MLH1 Antibody (aa557-756) LS-C9063

Antibody:

MLH1 Rabbit anti-Human Monoclonal (aa557-756) Antibody

Applications:

ELISA, WB

Format:

Unconjugated

Price:

20 µl/$469

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MLH1 Antibody (Amino Acid: 381-483, clone 4C9C7) LS-C758540

Antibody:

MLH1 Mouse anti-Human Monoclonal (Amino Acid: 381-483) (4C9C7) Antibody

Reactivity:

Human, Non-Human Primate

Applications:

ICC, IF, IHC, WB

Format:

Unconjugated

Price:

100 µl/$518

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MLH1 Antibody LS-C678660

Antibody:

MLH1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µg/$294; 100 µg/$360

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MLH1 Antibody LS-C812814

Antibody:

MLH1 Mouse anti-Human Monoclonal Antibody

Reactivity:

Human, Monkey

Applications:

ELISA, IF, IHC, WB

Format:

Unconjugated

Price:

50 µg/$332; 100 µg/$404; 200 µg/$505

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MLH1 Antibody (aa1-298, clone OTI4B5) LS-C796134

Antibody:

MLH1 Mouse anti-Human Monoclonal (aa1-298) (OTI4B5) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$434

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MLH1 Antibody (aa299-527, clone UMAB191) LS-C796936

Antibody:

MLH1 Mouse anti-Human Monoclonal (aa299-527) (UMAB191) Antibody

Reactivity:

Human

Applications:

IF, IHC, WB

Format:

Unconjugated

Price:

100 µl/$493

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MLH1 Antibody (aa299-527, clone UMAB191, Carrier-free) LS-C796941

Antibody:

MLH1 Mouse anti-Human Monoclonal (aa299-527) (Carrier-free) (UMAB191) Antibody

Reactivity:

Human

Applications:

IF, IHC, WB

Format:

Unconjugated, Carrier-free

Price:

100 µg/$539

• Unconjugated
• Unconjugated, Carrier-free

• Unconjugated
• Unconjugated, Carrier-free

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MLH1 Antibody (clone ABT-MLH1) LS-C744536

Antibody:

MLH1 Mouse anti-Human Monoclonal (ABT-MLH1) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µl/$268; 100 µl/$316

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MLH1 Antibody LS-C666790

Antibody:

MLH1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IP, WB

Format:

Unconjugated

Price:

100 µg/$331

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Human MLH1 Protein (Recombinant GST) (Full Length) - LS-G29342

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

108.9 kDa

Price:

10 µg/$479; 25 µg/$670

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MLH1 Antibody (aa299-527, clone OTI4H6) LS-C795358

Antibody:

MLH1 Mouse anti-Human Monoclonal (aa299-527) (OTI4H6) Antibody

Reactivity:

Human

Applications:

IHC, WB

Format:

Unconjugated

Price:

100 µl/$434

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MLH1 Antibody (aa299-527, clone OTI4H6, Carrier-free) LS-C792401

Antibody:

MLH1 Mouse anti-Human Monoclonal (aa299-527) (Carrier-free) (OTI4H6) Antibody

Reactivity:

Human

Applications:

IHC, WB

Format:

Unconjugated, Carrier-free

Price:

100 µg/$511

• Unconjugated
• Unconjugated, Carrier-free

• Unconjugated
• Unconjugated, Carrier-free

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MLH1 Antibody (aa299-527, clone OTI3D1) LS-C795365

Antibody:

MLH1 Mouse anti-Human Monoclonal (aa299-527) (OTI3D1) Antibody

Reactivity:

Human

Applications:

IHC, WB

Format:

Unconjugated

Price:

100 µl/$434

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MLH1 Antibody (aa299-527, clone OTI3D1, Carrier-free) LS-C792406

Antibody:

MLH1 Mouse anti-Human Monoclonal (aa299-527) (Carrier-free) (OTI3D1) Antibody

Reactivity:

Human

Applications:

IHC, WB

Format:

Unconjugated, Carrier-free

Price:

100 µg/$511

• Unconjugated
• Unconjugated, Carrier-free

• Unconjugated
• Unconjugated, Carrier-free

Select

MLH1 Antibody (aa299-527, clone OTI3C1) LS-C795361

Antibody:

MLH1 Mouse anti-Human Monoclonal (aa299-527) (OTI3C1) Antibody

Reactivity:

Human

Applications:

IHC, WB

Format:

Unconjugated

Price:

100 µl/$434

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MLH1 Antibody (aa299-527, clone OTI3C1, Carrier-free) LS-C798773

Antibody:

MLH1 Mouse anti-Human Monoclonal (aa299-527) (Carrier-free) (OTI3C1) Antibody

Reactivity:

Human

Applications:

IHC, WB

Format:

Unconjugated, Carrier-free

Price:

100 µg/$511

• Unconjugated
• Unconjugated, Carrier-free

• Unconjugated
• Unconjugated, Carrier-free

Select

MLH1 Antibody LS-C836169

Antibody:

MLH1 Rabbit Recombinant Monoclonal Antibody

Applications:

ICC, IHC, IP, WB

Format:

Unconjugated

Price:

10 µl/$299; 100 µl/$548

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