Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Essential transmembrane GTPase, which mediates mitochondrial fusion. Fusion of mitochondria occurs in many cell types and constitutes an important step in mitochondria morphology, which is balanced between fusion and fission. MFN2 acts independently of the cytoskeleton. It therefore plays a central role in mitochondrial metabolism and may be associated with obesity and/or apoptosis processes. Overexpression induces the formation of mitochondrial networks.
Immunoperoxidase of monoclonal antibody to MFN2 on formalin-fixed paraffin-embedded human heart. [antibody concentration 5 ug/ml]
Western blot of MFN2 expression in transfected 293T cell line by MFN2 monoclonal antibody (M03), clone 4H8.
MFN2 monoclonal antibody (M03), clone 4H8 Western blot of MFN2 expression in HeLa.
MFN2 monoclonal antibody (M03), clone 4H8. Western blot of MFN2 expression in PC-12.
Enzyme-Linked Immunosorbent Assay
Detection limit for recombinant GST tagged MFN2 is approximately 1 ng/ml as a capture antibody.
Western blot of MFN2 over-expressed 293 cell line, cotransfected with MFN2 Validated Chimera RNAi (Lane 2) or non-transfected control (Lane 1). Blot probed with MFN2 monoclonal antibody, clone 4H8. GAPDH ( 36.1 kD ) used as specificity an.