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Anti-MICA/B Antibody (clone 6D4, Biotin) LS-C44798

Note: This antibody replaces LS-C57930

Ordering

Wt. Vol. Conc. Price
100 µg - 0.1 mg/ml $350
Inquire for larger quantities

LSBio (Direct) LSBio (Direct)
206-374-1102
866-206-6909
Orders@LSBio.com
 

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Most Popular MICA/B Antibodies

Anti-MICA/B Antibody (clone 6D4) LS-C40907
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IHC, Flow Cytometry
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Flow Cytometry Image
Anti-MICA/B Antibody LS-C44797
Mouse Monoclonal (IgG2a) to Human MICA/B
Human
IHC - Frozen, Immunoprecipitation, Flow Cytometry
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Anti-MICA/B Antibody (FITC) LS-C44800
Mouse Monoclonal (IgG2a) to Human MICA/B
Human
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100% Guaranteed 100% Guaranteed
Mouse Monoclonal [clone 6D4] (IgG2a) to Human MICA/B
Human
IHC - Frozen, Immunoprecipitation, Flow Cytometry (applications tested for the base form of this product only)
Biotin Conjugated

Details

Human MICA/B
Mouse
Human (tested or 100% immunogen sequence identity)
IgG2a Monoclonal [6D4]
Biotin. Also available Unconjugated or conjugated with FITC.
Protein G purified
Unmodified

Applications

  • IHC - Frozen (1:1 - 1:10)
  • Immunoprecipitation
  • Flow Cytometry
  • (applications tested for the base form of this product only)

Specificity and Use

MICA/B antibody was raised against mICA transfected C1R cells.
Specific for nonclassical MHC class I chain A (MICA) and nonclassical MHC class I chain MICB (MICB). MICA and MICB are stress inducible antigens, which are closely related and appear functionally indistinguishable. MICA and MICB are ligands for NKG2D, an activating receptor on most natural killer (NK) cells, CD8 T cells and gamma delta T cells. MICA is principally expressed on intestinal epithelium, and several epithelial tumors. Expression may be induced to high surface levels by heat shock, oxidative stress, and virus infection. Clone 6D4 is reported to inhibit the cytotoxicity of NK cells stimulated by IFN alpha-treated dendritic cells. XXX recommend the use of MCA2403EL for such studies.
The applications listed have been tested for the unconjugated form of this product. Other forms have not been tested. Flow Cytometry: Use 10 ul of the suggested working dilution to label 1x10^6 cells in 100 ul. Method sheets are available on request. Membrane permeabilization is required for this application.

Packaging

PBS, pH 7.4, 0.09% sodium azide, 1% BSA.
For research use only.

About MICA/B


Requested From: United States
Date Requested: 12/3/2016

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