Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Mouse Monoclonal (IgG2a,k) to Rabbit MHC Class II RLA-DQ
IHC - Frozen, Immunoprecipitation, Flow Cytometry
Rabbit MHC Class II RLA-DQ
Rabbit (tested or 100% immunogen sequence identity)
IHC - Frozen
Specificity and Use
Rabbit Spleen Cells.
Recognizes rabbit RLA-DQ alpha chain (Mr ~35kD). Reacts with RLA-DQ-transfected cells, but not with RLA-DR-transfected cells. In normal adult rabbits, the antibody reacts with 30-60% of peripheral blood leukocytes. It has also been reported that the antibody stains: lymphocytes and macrophages in the spleen; lymphocytes in the thymic medulla and some cells in the cortex; Kupffer cells in the liver; and synovial lining cells (i. e., infiltrating macrophages) in inflamed synovium.
Flow cytometry. Immunohistochemistry (acetone-fixed, frozen tissue sections). Immunoprecipitation. Flow Cytometry: 0.2 ug/1E6 cells. The applications listed have been tested for the unconjugated form of this product. Other forms have not been tested.