Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Mouse Monoclonal [clone 14V.18] (IgG2a) to Mouse MHC Class II I-Ak (private; Ia. m2)
Mouse MHC Class II I-Ak (private; Ia. m2)
Mouse (tested or 100% immunogen sequence identity)
IgG2a Monoclonal [14V.18]
Protein G purified
Flow Cytometry (1 µg/10E6 cells)
Specificity and Use
A. TL spleen.
Anti-I-Ak monoclonal antibody is a cytotoxic antibody specific for cells expressing the Ia antigen coded for by the A subregion of the k haplotype. The reaction pattern of this antibody with a panel of inbred and recombinant haplotypes demonstrates that t