Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Mouse Monoclonal [clone VPM54] (IgG1) to Sheep MHC Class II DR Monomorphic
IHC - Frozen, Western blot, Immunoprecipitation, Flow Cytometry
Sheep MHC Class II DR Monomorphic
Sheep, Bovine (tested or 100% immunogen sequence identity)
IgG1 Monoclonal [VPM54]
Tissue culture supernatant
IHC - Frozen
Flow Cytometry (1:1)
Specificity and Use
Acid treated SW73.2 purified Ag.
The major histocompatibility complex (MHC) is a cluster of genes some of which are important in the immune response to infections. In sheep, this complex is referred to as the ovine leukocyte antigen (OLA) region. There are 2 major types of MHC class IIa molecules encoded by the OLA which are DR and DQ each composed of an alpha and beta chain. The antibody recognizes a monomorphic epitope on the alpha chain of ovine MHC Class II DR molecules, which are constitutively expressed on antigen presenting cells such as dendritic cells, B lymphocytes, monocytes, macrophages, activated T lymphocytes and may be induced on a range of other cell types by interferon gamma.