Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Mouse Monoclonal [clone 28.1] (IgG1) to Sheep MHC Class II DQ DR
Sheep, Bovine, Goat
IHC - Frozen, Immunoprecipitation, Flow Cytometry (applications tested for the base form of this product only)
Sheep MHC Class II DQ DR
Sheep, Bovine, Goat (tested or 100% immunogen sequence identity)
IgG1 Monoclonal [28.1]
IHC - Frozen
Flow Cytometry (1:1 - 1:5)
(applications tested for the base form of this product only)
Specificity and Use
Ovine alveolar macrophages.
Recognizes a polymorphic epitope on ovine MHC class II DQ and DR molecules. In recent work, this clone was found to recognize ovine MHC II transfectants DQ-T28.1, DQ - T26.2 and DR - T31.3 but not DR - T8.1 (Ballingall. K. et al.1995)Ovine MHC class II antigens are expressed on several cell types, including B cells, activated T cells, monocytes, macrophages and dendritic cells.
The applications listed have been tested for the base form of this product. Alternate forms, such as conjugated, azide-free, or ready-to-use, have not been tested. Flow Cytometry: Use 10 ul of the suggested working dilution to label 10^6 cells in 100 ul. Method sheets are available on request.
PBS, pH 7.4, 0.09% sodium azide, 1% BSA.
Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.