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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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MHC Class II Antibody (clone ER‑TR3) LS‑C96380
Antibody
MHC Class II antibody LS-C96380 is an unconjugated rat monoclonal antibody to mouse MHC Class II. Validated for IHC.
Catalog
Size
Price
LS-C96380-150
150 µg
Unavailable

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Anti-MHC Class II antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B6315 concentration 10 ug/ml.
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Product Description

MHC Class II antibody LS-C96380 is an unconjugated rat monoclonal antibody to mouse MHC Class II. Validated for IHC.
About MHC Class II
MHC (major histocompatibility complex) class II molecules are a family of molecules normally found only on antigen-presenting cells such as dendritic cells, mononuclear phagocytes, some endothelial cells, thymic epithelial cells, and B cells. The antigens presented by class II peptides are derived from extracellular proteins (not cytosolic as in class I); hence, the MHC class II-dependent pathway of antigen presentation is called the endocytic or exogenous pathway.

Specifications

Target
MHC Class II
Host
Rat
Reactivity
Mouse (tested or 100% immunogen sequence identity)
Clonality
Monoclonal [ER-TR3]
Conjugations
Unconjugated
Purification
Affinity purified
Modifications
Unmodified
Applications
  • IHC
  • IHC - Frozen (1:200)
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Immunogen
MHC Class II antibody was raised against murine thymic reticulum
Specificity
MHC Class II antigens are heterodimers consisting of one a- chain (31-34kDa) and one beta-chain (26-29kDa). The epitope has not been further characterized. Antigen distribution Isolated cells: The antigen is found on dendritic cells, B-cells and macrophages. The level of antigen detected by ER-TR1, ER-TR2 and ER-TR3 differs from strain to strain (see table below). Tissue Sections: The antigen is found on B-cells, interdigitating cells and macrophages in peripheral lymphoid organs but is absent from T-cells. It is also expressed as a fine reticular pattern on stromal thymic cells of the cortex and as a confluent pattern on stromal thymic cells of the medulla. Specificity: Mouse: cells expressing MHC class II antigens Other species: negative on human, other unknown
Presentation
Lyophilized from PBS pH 7.2, 5mg/ml BSA, 0.09% sodium azide
Reconstitution
0.5ml distilled water
Storage
Store at 4°C.
Restrictions
For research use only.
Guarantee
This antibody carries the LSBio 100% Guarantee.

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Requested From: 
Date Requested: 6/21/2018

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