Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Mouse Monoclonal [clone 34-1-2S] (IgG2a,k) to Mouse MHC Class I H-2Kd, Dd
IHC - Frozen, Flow Cytometry, Cytotoxic Assay
Mouse MHC Class I H-2Kd, Dd
Mouse (tested or 100% immunogen sequence identity)
IgG2a,k Monoclonal [34-1-2S]
IHC - Frozen
Specificity and Use
C3H. SW mouse splenocytes.
Recognizes an epitope in the alpha3 domain that is common to H-2Kd and H-2Dd. Binds to a common determinant in the alpha3 domains of H-2Kd and H-2Dd in the presence or absence of b2 microglobulin. It cross-reacts with the alpha3 domain of H-2Kb.
Flow cytometry. Immunohistochemistry (acetone-fixed, frozen tissue sections). Complement-mediated cytotoxicity. Flow Cytometry: 1 ug/1E6 cells. The applications listed have been tested for the unconjugated form of this product. Other forms have not been tested.