Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Mouse Monoclonal [clone 15-5-5.3] (IgG2a,k) to Mouse MHC Class I H-2Dk
Flow Cytometry, Cytotoxic Assay
Mouse MHC Class I H-2Dk
Mouse (tested or 100% immunogen sequence identity)
IgG2a,k Monoclonal [15-5-5.3]
Specificity and Use
C3H mouse splenocytes.
Reacts with the H-2Dk class I alloantigen. It cross-reacts with H-2Kd and with cells from mice with the H-2f haplotype. Does not react with other (e. g., a, b, p, q, r, s) haplotypes.
Flow cytometry. Complement-dependent cytotoxicity. Flow Cytometry: 0.2 ug/1E6 cells. The applications listed have been tested for the unconjugated form of this product. Other forms have not been tested.