Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Mouse Monoclonal (IgG2a,k) to Mouse MHC Class I H-2Dd
Immunoprecipitation, Flow Cytometry
Mouse MHC Class I H-2Dd
Mouse (tested or 100% immunogen sequence identity)
Specificity and Use
C57BL/6 x DBA/2) F1 hybrid mouse splenocytes.
Reacts with a conformational epitope on H-2Dd MHC Class I found on the N-terminal domains of alpha1 and alpha2 chains when complexed with b2-microglobulin. Does not react with H-2Dd alpha chains synthesized in vitro. Weak cross-reactivity with cells from mice of the H-2b, H-2q, and H-2s haplotypes has been observed by flow cytometric analysis. Reactivity with cells from mice of the H-2f, H-2k, H-2p, and H-2r haplotypes has not been observed.
Suitable for use in Flow Cytometry, Immunoprecipitation, Immunoaffinity chromatography and Antigen blocking.
Borate buffered saline, pH 8.0. No preservatives or amine-containing buffer salts added.