Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Mouse Monoclonal [clone D1] (IgG2a) to Mouse MHC Class I H-2Dd
Flow Cytometry, Cytotoxic Assay
Mouse MHC Class I H-2Dd
Mouse (tested or 100% immunogen sequence identity)
IgG2a Monoclonal [D1]
Flow Cytometry (1:1)
Specificity and Use
Recognizes the murine MHC Class I H-2Dd haplotype. The major histocompatibility complex (MHC) is a cluster of genes that are important in the immune response to infections. In mice, this complex is referred to as the histocompatibility 2 (H-2) region. There are 3 major MHC class I proteins encoded by the H-2 which are H-2K, H-2L and H-2D. The H- 2D gene is part of the murine H-2 complex on chromosome 17 and there are a large number of variant alleles of this gene. Recognizes the H-2Dd determinant present on all nucleated cells of mice expressing this MHC class I haplotype.
Flow Cytometry: Use 10 ul of the suggested working dilution to label 10^6 cells in 100 ul. Method sheets are available on request.