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MGRN1
mahogunin ring finger 1, E3 ubiquitin protein ligase
E3 ubiquitin-protein ligase. Mediates monoubiquitination at multiple sites of TSG101 in the presence of UBE2D1, but not of UBE2G1, nor UBE2H. Plays a role in the regulation of endosome-to-lysosome trafficking. Impairs MC1R- and MC4R-signaling by competing with GNAS-binding to MCRs and inhibiting agonist-induced cAMP production. Does not inhibit ADRB2-signaling. Does not promote MC1R ubiquitination.
| Gene Name: | mahogunin ring finger 1, E3 ubiquitin protein ligase |
| Synonyms: | MGRN1, KIAA0544, Mahogunin, ring finger 1, RNF156, RING finger protein 156 |
| Target Sequences: | AB011116 BAA25470.1 O60291 |
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Products
Antibodies
(35)
Proteins
(9)
Type
Over-Expression Lysate
(6)
Primary
(35)
Recombinant
(3)
Target
MGRN1
(44)
Reactivity
Human
(35)
Mouse
(5)
Rat
(5)
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(3)
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(3)
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(3)
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(3)
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(3)
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(5)
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(3)
Application
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(2)
WB
(34)
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(14)
ELISA
(8)
IF
(17)
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(2)
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(1)
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rabbit
(15)
mouse
(20)
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IgG
(14)
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(14)
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(6)
Clonality
monoclonal mc
(20)
polyclonal pc
(15)
Clone
OTI1A11
(2)
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(2)
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(2)
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(2)
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(2)
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(2)
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(2)
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APC Conjugated
(2)
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(3)
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(7)
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(3)
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(3)
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(2)
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(22)
Epitope
aa252-301
(4)
aa400-450
(1)
aa477-577
(1)
aa505-555
(1)
Publications
No
(44)
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GST
(1)
GST, N-terminus
(1)
Myc-DDK (Flag)
(7)
Species
Human
(6)
Source
293T Cells
(3)
HEK 293 Cells
(4)
Wheat Germ Extract
(2)
Purification
Purified
(1)
MGRN1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, WB
Unconjugated
100 µg/$331
MGRN1 Rabbit anti-Human Polyclonal (aa252-301) Antibody
Human
WB
Unconjugated
100 µl/$424
MGRN1 Mouse anti-Human Monoclonal (OTI3A6) Antibody
Human
Flo, IF, WB
Unconjugated
100 µl/$434
MGRN1 Mouse anti-Human Monoclonal (Carrier-free) (OTI3A6) Antibody
Human
Flo, IF, WB
Unconjugated, Carrier-free
100 µg/$511
MGRN1 Mouse anti-Human Monoclonal (OTI3A1) Antibody
Human
Flo, IF, WB
Unconjugated
100 µl/$434
MGRN1 Mouse anti-Human Monoclonal (Carrier-free) (OTI3A1) Antibody
Human
Flo, IF, WB
Unconjugated, Carrier-free
100 µg/$511
MGRN1 Mouse anti-Human Monoclonal (OTI3C3) Antibody
Human, Monkey
Flo, IF, WB
Unconjugated
100 µl/$434
MGRN1 Mouse anti-Human Monoclonal (Carrier-free) (OTI3C3) Antibody
Human, Monkey
Flo, IF, WB
Unconjugated, Carrier-free
100 µg/$511
MGRN1 Mouse anti-Human Monoclonal (OTI1A8) Antibody
Human
Flo, IF, WB
Unconjugated
100 µl/$434
MGRN1 Mouse anti-Human Monoclonal (Carrier-free) (OTI1A8) Antibody
Human
Flo, IF, WB
Unconjugated, Carrier-free
100 µg/$511
MGRN1 Mouse anti-Human Monoclonal (OTI1E12) Antibody
Human
Flo, IF, WB
Unconjugated
100 µl/$434
MGRN1 Mouse anti-Human Monoclonal (Carrier-free) (OTI1E12) Antibody
Human
Flo, IF, WB
Unconjugated, Carrier-free
100 µg/$511
MGRN1 Mouse anti-Human Monoclonal (OTI2A7) Antibody
Human
Flo, IF, WB
Unconjugated
100 µl/$434
MGRN1 Mouse anti-Human Monoclonal (Carrier-free) (OTI2A7) Antibody
Human
Flo, IF, WB
Unconjugated, Carrier-free
100 µg/$511
MGRN1 Mouse anti-Human Monoclonal (aa477-577) Antibody
Human
ELISA, IF, WB
Unconjugated
100 µg/$705
MGRN1 Mouse anti-Human Monoclonal (HRP) Antibody
Human
ELISA, WB
HRP Conjugated
100 µl/$904
MGRN1 Mouse anti-Human Monoclonal (Biotin) Antibody
Human
ELISA, IF, WB
Biotin Conjugated
100 µl/$904
MGRN1 Mouse anti-Human Monoclonal (FITC) Antibody
Human
ELISA, IF, WB
FITC Conjugated
100 µl/$904
MGRN1 Mouse anti-Human Monoclonal (PE) Antibody
Human
ELISA, IF, WB
PE Conjugated
100 µl/$904
MGRN1 Mouse anti-Human Monoclonal (APC) Antibody
Human
ELISA, IF, WB
APC Conjugated
100 µl/$904
MGRN1 Mouse anti-Human Monoclonal (OTI1A11) Antibody
Human
Flo, WB
Unconjugated
100 µl/$434
MGRN1 Mouse anti-Human Monoclonal (Carrier-free) (OTI1A11) Antibody
Human
Flo, WB
Unconjugated, Carrier-free
100 µg/$511
MGRN1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
MGRN1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, WB
Unconjugated
100 µg/$357
MGRN1 Rabbit anti-Human Polyclonal (aa400-450) Antibody
Human
IP, WB
Unconjugated
10 µl/$295; 100 µl/$514
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product results
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