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MGMT
O-6-methylguanine-DNA methyltransferase
Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.
| Gene Name: | O-6-methylguanine-DNA methyltransferase |
| Synonyms: | MGMT |
| Target Sequences: | NM_002412 NP_002403.2 P16455 |
Publications (7)
1
Differential degradation rates of inactivated alkyltransferase in blood mononuclear cells and tumors of patients after treatment with O(6)-benzylguanine. Liu L, Spiro TP, Qin X, Majka S, Haaga J, Schupp J, Willson JK, Gerson SL. Clinical cancer research : an official journal of the American Association for Cancer Research. 2001 7:2318-24. (IHC; Human)
[PubMed:11489807]
2
Human-yeast chimeric repair protein protects mammalian cells against alkylating agents: enhancement of MGMT protection. Roth TJ, Xu Y, Luo M, Kelley MR. Cancer gene therapy. 2003 10:603-10. (WB)
[PubMed:12872142]
3
O6-methylguanine-DNA methyltransferase gene: epigenetic silencing and prognostic value in head and neck squamous cell carcinoma. Zuo C, Ai L, Ratliff P, Suen JY, Hanna E, Brent TP, Fan CY. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 2004 13:967-75. (IHC; Human)
[PubMed:15184253]
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MGMT Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, IHC-P, WB
Unconjugated
50 µl/$460
MGMT Rabbit anti-Human Polyclonal (aa156-182) Antibody
Human
Flo, IHC, IHC-P, WB
Unconjugated
400 µl/$393
Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Tissue Homogenates
1 Plate/$834
MGMT Mouse anti-Human Monoclonal (UMAB56) Antibody
Human, Monkey
IF, IHC, WB
Unconjugated
100 µl/$493
MGMT Mouse anti-Human Monoclonal (Carrier-free) (UMAB56) Antibody
Human, Monkey
IF, IHC, WB
Unconjugated, Carrier-free
100 µg/$539
MGMT Rabbit anti-Human Polyclonal (aa143-192) Antibody
Human
WB
Unconjugated
100 µl/$424
Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$768
MGMT Mouse anti-Human Monoclonal (MT 23.2) Antibody
Human
ICC, IF, IHC, WB
Unconjugated
0.1 ml/$386
MGMT Mouse anti-Human Monoclonal (1A11F8) Antibody
Human
ELISA, Flo, IF, IHC, WB
Unconjugated
100 µl/$459
MGMT Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$321
MGMT Mouse anti-Human Monoclonal Antibody
Human
Flo, IF, IHC, IHC-P, IP, WB
Unconjugated
100 µg/$813
MGMT Mouse anti-Human Monoclonal (HRP) Antibody
Human
Flo, IF, IHC, IP, WB
HRP Conjugated
100 µl/$1,038
MGMT Mouse anti-Human Monoclonal (Biotin) Antibody
Human
Flo, IF, IHC, IP, WB
Biotin Conjugated
100 µl/$1,038
MGMT Mouse anti-Human Monoclonal (FITC) Antibody
Human
Flo, IF, IHC, IP, WB
FITC Conjugated
100 µl/$1,038
MGMT Mouse anti-Human Monoclonal (PE) Antibody
Human
Flo, IF, IHC, IP, WB
PE Conjugated
100 µl/$1,038
MGMT Mouse anti-Human Monoclonal (APC) Antibody
Human
Flo, IF, IHC, IP, WB
APC Conjugated
100 µl/$1,038
MGMT Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
MGMT Rabbit anti-Human Polyclonal (aa2-207) Antibody
Human
ICC, IHC, IHC-P, WB
Unconjugated
10 µg/$318; 100 µg/$470
MGMT Mouse anti-Human Monoclonal (UMAB52) Antibody
Human, Monkey
IF, IHC, WB
Unconjugated
100 µl/$493
MGMT Mouse anti-Human Monoclonal (Carrier-free) (UMAB52) Antibody
Human, Monkey
IF, IHC, WB
Unconjugated, Carrier-free
100 µg/$539
MGMT Rabbit anti-Human Polyclonal Antibody
ELISA, IF, IHC, WB
Unconjugated
500 µg/$725
MGMT Mouse anti-Human Monoclonal (aa8-221) Antibody
Human
Flo, IHC, IHC-P, WB
Unconjugated
500 µl/$866
MGMT Mouse anti-Human Monoclonal Antibody
Human
Flo, IHC, IHC-P, WB
Unconjugated
100 µg/$842
MGMT Rabbit anti-Human Polyclonal Antibody
Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
MGMT Rabbit anti-Human Polyclonal (aa1-30) (APC) Antibody
Human
ELISA, ICC, IF, WB
APC Conjugated
200 µl/$952
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product results
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