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Anti-MEN1 / Menin Antibody (aa575-615) LS-C56963

Ordering

Wt. Vol. Conc. Price
50 µg - - $350
Inquire for larger quantities

LSBio (Direct) LSBio (Direct)
206-374-1102
866-206-6909
Orders@LSBio.com
 

Most Popular MEN1 / Menin Antibodies

Anti-MEN1 / Menin Antibody (aa128-144) LS-C3127
Rabbit Polyclonal to Mouse MEN1 / Menin
Mouse, Human, Monkey, Rat, Bat, Bovine, Dog, Hamster, Horse, Rabbit, Zebrafish
ELISA
Unconjugated
Anti-MEN1 / Menin Antibody (C-Terminus) IHC-plus™ LS-B11066
Rabbit Polyclonal (IgG) to Human MEN1 / Menin
Human, Mouse
IHC - Paraffin, Immunofluorescence
Unconjugated
Immunohistochemistry Image
Anti-MEN1 / Menin Antibody (aa181-230) IHC-plus™ LS-B12524
Rabbit Polyclonal (IgG) to Human MEN1 / Menin
Human, Mouse, Rat
IHC - Paraffin, Western blot, ELISA
Unconjugated
Immunohistochemistry - Paraffin Image

100% Guaranteed 100% Guaranteed
Rabbit Polyclonal to Human MEN1 / Menin
Human, Mouse
IHC - Paraffin, Western blot, Immunoprecipitation
Unconjugated

Details

Human MEN1 / Menin
Rabbit
Human, Mouse (tested or 100% immunogen sequence identity)
Rat (at least 90% immunogen sequence identity)
Polyclonal
Unconjugated
Affinity purified
Unmodified

Applications

  • IHC - Paraffin (1:100 - 1:250)
  • Western blot (1:1000 - 1:10000)
  • Immunoprecipitation

Specificity and Use

MEN1 / Menin antibody was raised against synthetic peptide corresponding to an epitope within amino acid residues 575-615 of human menin (NP_000235.2).
aa575-615
Recognizes the nuclear protein MCM2 (mini chromosome maintenance protein 2), when phosphorylated at Ser41. MCM2 is a putative DNA replicative helicase and member of the MCM family, critical during the initiation of DNA replication. During the G1 phase of the cell cycle the MCM proteins, part of the pre-replicative complex which assembles at replication origins, undergo phosphorylation by kinases including cyclin dependent kinase (CDK) and Cdc7/Dbf4 (DDK). Studies have shown that the phosphorylation of MCM2 occurs on multiple sites, namely Ser27, Ser41, Ser53, Ser108 and Ser139 and that phosphorylation results in a conformational change of the complex and activation of the helicase activity.
Immunohistochemistry: This product requires antigen retrieval using heat treatment prior to staining of paraffin sections. Sodium citrate buffer pH 6.0 is recommended for this purpose. Western Blot: LS-C56963 detects a band of approximately 68kD in 293T cell lysates.

Packaging

Tris-citrate/phosphate, 0.09% sodium azide.
Long term: -20°C; Short term: -20°C
For research use only.

About MEN1 / Menin

O00255 NM_000244 NP_000235.2

MEN1 Antibody, MEAI Antibody, Menin Antibody, Multiple endocrine neoplasia I Antibody

Essential component of a MLL/SET1 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3 (H3K4). Functions as a transcriptional regulator. Binds to the TERT promoter and represses telomerase expression. Plays a role in TGFB1-mediated inhibition of cell-proliferation, possibly regulating SMAD3 transcriptional activity. Represses JUND-mediated transcriptional activation on AP1 sites, as well as that mediated by NFKB subunit RELA.

Western blot

Western blot
Detection of human menin in a whole cell lysate from 293T cells using Western blotting and immunoprecipitation as indicated in the presence or absence of blocking peptide with Rabbit anti-Human menin (LS-C56963).
 

Requested From: United States
Date Requested: 12/6/2016

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