Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Mouse Monoclonal [clone HMB-45] (IgG1) to Human Melanoma Marker HMB45
IHC - Paraffin, IHC - Frozen
Human Melanoma Marker HMB45
Human (tested or 100% immunogen sequence identity)
IgG1 Monoclonal [HMB-45]
IHC - Paraffin
IHC - Frozen
Specificity and Use
Extract of pigmented melanoma metastases from lymph nodes.
Recognizes the HMB-45 antigen, an intracytoplasmic antigen expressed by the majority of melanomas and with other tumors demonstrating melanocytic differentiation. Tumors of lymphoid, epithelial, glial and mesenchymal origin are negative.