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Anti-Melanoma-Associated Antigen Antibody (clone NKI-C3) IHC-plus™ LS-B7204

Note: This antibody replaces LS-C149086, LS-C150499

Ordering

Wt. Vol. Conc. Price
50 µg 50 µl 1 mg/ml $395
Inquire for larger quantities

LSBio (Direct) LSBio (Direct)
206-374-1102
866-206-6909
Orders@LSBio.com
 

Most Popular Melanoma-Associated Antigen Antibodies

Anti-Melanoma-Associated Antigen Antibody (clone NKI-beteb) LS-C149087
Mouse Monoclonal [clone NKI-beteb] (IgG2b) to Human Melanoma-Associated Antigen
Human
IHC - Frozen
Unconjugated
Anti-Melanoma-Associated Antigen Antibody (clone NKI-C3) IHC-plus™ LS-B7204
Mouse Monoclonal [clone NKI-C3] (IgG1) to Human Melanoma-Associated Antigen
Human
IHC - Paraffin, IHC - Frozen, Immunofluorescence, Immunoprecipitation, ELISA
Unconjugated
Immunohistochemistry Image

100% Guaranteed 100% Guaranteed
Mouse Monoclonal [clone NKI-C3] (IgG1) to Human Melanoma-Associated Antigen
Human
IHC - Paraffin, IHC - Frozen, Immunofluorescence, Immunoprecipitation, ELISA
Unconjugated

Details

Human Melanoma-Associated Antigen
Mouse
Human (tested or 100% immunogen sequence identity)
IgG1 Monoclonal [NKI-C3]
Unconjugated
Purified
Unmodified

Applications

  • IHC - Paraffin (10 µg/ml)
  • IHC - Frozen
  • Immunofluorescence
  • Immunoprecipitation
  • ELISA

Specificity and Use

Melanoma-associated antigen
Used for diagnostic by staining of lysosomes/melanosomes. Directed against a predominantly intracellular protein of human melanoma cells. The antigen is abundantly present in malignant melanomas, nevocellular nevi, and neuroendocrine tumors, whereas it has not been detectable in most other tissues. The antigen recognized is a glycoprotein which appears as a broad band in SDS-PAGE. The antigen was shown to consist of a single protein backbone to which two or three V-linked glycans were added cotranslationally. Extensive further heterogeneity was generated in the Colgi compartmen and was shown to be dependent on the presence of complex type sugars. Although the antigen is associated with melanomas, it was not codistributed with the tyrosinase activity associated with melanogenesis. The antigen did show codistribution with cathepsin D, which is a marker for lysosomal functions.This antibody was originally described as a marker for melanoma. Recently, it resurfaced as a marker to separate cellular neurothekeoma from other dermal tumors in the differential diagnosis.

Packaging

PBS containing 0.09% sodium azide.
Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted.
For research use only.

About Melanoma-Associated Antigen


Immunohistochemistry

Immunohistochemistry
Anti-Melanoma-Associated Antigen antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B7204 concentration 10 ug/ml.
 

Requested From: United States
Date Requested: 12/3/2016

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