Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Mouse Monoclonal [clone PNL2] (IgG1) to Human Melanoma
IHC - Paraffin
Human (tested or 100% immunogen sequence identity)
IgG1 Monoclonal [PNL2]
Tissue culture supernatant
IHC - Paraffin (1:10 - 1:25)
Specificity and Use
Melanoma antibody was raised against synthetic peptide from human Melanoma.
Labels melanocytes and is useful tool for the identification of melanomas and clear cell sarcomas. Anti-Melanoma, PNL2, seems to be a melanocyte antibody of autoimmune origin as it does not react with the non-melanocytic peptide antigen used for immunization.
Requires HIER antigen retrieval with 1 mM EDTA buffer pH 9.0 before immunostaining.