• Antibodies
  • All Antibodies
  • Primary Antibodies
  • Secondary Antibodies
  • IHC-plus Antibodies
  • Isotype Control Antibodies
  • ELISA and Assay Kits
  • All Kits
  • Assay Kits
  • Traditional ELISA Kits
  • Cell-Based ELISA Kits
  • DNA-Binding ELISA Kits
  • Phospho-Specific ELISA Kits
  • ELISA Development Kits
  • Chemiluminescent CLIA Kits
  • Proteins
  • All Proteins
  • Recombinant Proteins
  • Native Proteins
  • Over-expression Lysates
  • Cell and Tissue Lysates
  • Bio-active Proteins
  • Animal-free Proteins
  • Synthetic Peptides
  • Biochemicals
  • All Biochemicals

  • Immunohistochemistry
  • Immunohistochemistry Reagents
  • Comprehensive IHC Reports
  • Custom IHC Services
  • TCR Screening Services
  • IHC-plus Antibodies
  • Immunohistochemistry Services

  • Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

  • TCR Screening Services

  • Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Have a question?
  • Purchasing
  • Product Ordering Terms and Conditions
  • Holiday Schedule
  • About the LSBio Guarantee
  • About Reviews
  • Reference Material
  • About LSBio (LifeSpan BioSciences Inc.)
  • About Our 2-million Specimen Tissue Bank
  • About Our IHC Validation Process
  • About Our IHC-plus™ Immunohistochemistry Protocol
  • Protocols
  • Secure Logins
  • Login to Our Secure ShareFile Site
  • Login to Our IHC Database
Contact Us

2401 Fourth Avenue Suite 900
Seattle WA 98121

Phone: 866-819-4732 (Toll Free North America)
206-374-1102 (International)

Fax: 866-206-6909 (Toll Free North America)
206-577-4565 (International)
How to Buy - Details about how to buy our products. - To submit a new order. - To submit questions about existing orders, pricing, availability, bulk quotes, proforma invoice requests, or other billing issues. - To request technical information requests about an LSBio product or its application. - To request information about fee-for-service contract IHC studies, IHC reports, distribution agreements, or general business development.

Worldwide Distributors List - To find your local distributor if you're not within the United States.
Login ▾
Wish List
View Cart

Anti-Melanoma Antibody (clone 4A4) LS-C95605

Catalog Size Price
LS-C95605-0.5 0.5 ml Unavailable
LS-C95605-1 1 ml Unavailable

Related Products

20 Melanoma Antibodies

Most Popular Melanoma Antibodies

Anti-Melanoma Antibody (clone HMB45) LS-C95340
Mouse Monoclonal [clone HMB45] (IgG1,k) to Human Melanoma
IHC, Western blot
Immunohistochemistry Image
Anti-Melanoma Antibody (clone PNL2) LS-C95599
Mouse Monoclonal [clone PNL2] (IgG1) to Human Melanoma
IHC - Paraffin
Anti-Melanoma Antibody (clone PNL2, Ready-to-Use) LS-C391411
Mouse Monoclonal [clone PNL2] (IgG1) to Human Melanoma
Human, Mouse, Dog
IHC - Paraffin, Immunofluorescence
Unconjugated, Ready-to-Use
Immunohistochemistry Image
Anti-Melanoma Antibody (clone PNL2) LS-C391413
Mouse Monoclonal [clone PNL2] (IgG1) to Human Melanoma
Human, Mouse, Dog
IHC - Paraffin, Immunofluorescence
Immunohistochemistry Image
Anti-Melanoma Antibody (clone PNL2, Azide-free) LS-C391415
Mouse Monoclonal [clone PNL2] (IgG1) to Human Melanoma
Human, Mouse, Dog
IHC - Paraffin, Immunofluorescence
Unconjugated, Azide-free
Immunohistochemistry Image

100% Guaranteed
Mouse Monoclonal [clone 4A4] to Human Melanoma
IHC - Paraffin


Human Melanoma
Human (tested or 100% immunogen sequence identity)
Monoclonal [4A4]


IHC - Paraffin

Specificity and Use

Melanoma antibody was raised against pigmented melanoma metastases from lymph nodes(HMB45). Recombinant human MART-1 protein(MART1). Recombinant tyrosinase protein (Tyrosinase).
The HMB45 clone reacts with a neuraminidase-sensitive oligosaccharide side chain of a glycoconjugate present in immature melanosomes. The HMB45-reactive antigen is present in cutaneous melanocytes, prenatal and infantile retinal pigment epithelium and melanoma cells and is thought to be oncofetal in nature. has been shown to label the majority of melanomas. The MART-1/Melan A recognizes a protein of 18kDa, identified at MART-1 (Melanoma Antigen Recognized by T cells 1) or Melan-A. Melan-A is a useful addition to melanoma panels as it is apparently specific for melanocytic lesions. Studies have also shown that MART-1 is more sensitive than HMB45 when labeling metastatic melanomas. Tyrosinase is a key enzyme involved in the initial stages of melanin biosynthesis. Studies have shown Tyrosinase to be a more sensitive marker when compared to HMB45 and MART-1. It has also shown to label a higher percentage of desmoplastic melanomas than HMB45. The combination of HMB45 and the MART-1 (cocktail) and Tyrosinase make this quadruple antibody cocktail a first-order pan melanoma screener.


0.05% sodium azide
Store at 2-8°C. Do not freeze.
For research use only.

About Melanoma

Requested From: 
Date Requested: 3/17/2018

Get Social With Us! Follow us on Facebook Follow us on Google+ Follow us on LinkedIn PSL Alliance Member
Copyright © 2018 LifeSpan BioSciences, Inc. All Rights Reserved Privacy Policy

Catalog Number