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Anti-Melanoma Antibody (clone 4A4) LS-C95605

Ordering

Wt. Vol. Conc. Price
- 0.5 ml - $515
- 1 ml - $860
Inquire for larger quantities

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Most Popular Melanoma Antibodies

Anti-Melanoma Antibody (clone PNL2) LS-C95599
Mouse Monoclonal [clone PNL2] (IgG1) to Human Melanoma
Human
IHC - Paraffin
Unconjugated
Anti-Melanoma Antibody (clone PNL2) LS-C391413
Mouse Monoclonal [clone PNL2] (IgG1) to Human Melanoma
Human, Mouse, Dog
IHC - Paraffin, Immunofluorescence
Unconjugated
Immunohistochemistry Image

100% Guaranteed 100% Guaranteed
Mouse Monoclonal [clone 4A4] to Human Melanoma
Human
Unconjugated

Details

Human Melanoma
Mouse
Human (tested or 100% immunogen sequence identity)
Monoclonal [4A4]
Unconjugated
Unmodified

Specificity and Use

Melanoma antibody was raised against pigmented melanoma metastases from lymph nodes(HMB45). Recombinant human MART-1 protein(MART1). Recombinant tyrosinase protein (Tyrosinase).
The HMB45 clone reacts with a neuraminidase-sensitive oligosaccharide side chain of a glycoconjugate present in immature melanosomes. The HMB45-reactive antigen is present in cutaneous melanocytes, prenatal and infantile retinal pigment epithelium and melanoma cells and is thought to be oncofetal in nature. has been shown to label the majority of melanomas. The MART-1/Melan A recognizes a protein of 18kDa, identified at MART-1 (Melanoma Antigen Recognized by T cells 1) or Melan-A. Melan-A is a useful addition to melanoma panels as it is apparently specific for melanocytic lesions. Studies have also shown that MART-1 is more sensitive than HMB45 when labeling metastatic melanomas. Tyrosinase is a key enzyme involved in the initial stages of melanin biosynthesis. Studies have shown Tyrosinase to be a more sensitive marker when compared to HMB45 and MART-1. It has also shown to label a higher percentage of desmoplastic melanomas than HMB45. The combination of HMB45 and the MART-1 (cocktail) and Tyrosinase make this quadruple antibody cocktail a first-order pan melanoma screener.

Packaging

0.05% sodium azide
Store at 2°C to 8°C degrees. Do not freeze.
For research use only.

About Melanoma


Requested From: United States
Date Requested: 12/4/2016

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