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MEF2C

myocyte enhancer factor 2C

Transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes. Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. Plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. Crucial for normal neuronal development, distribution, and electrical activity in the neocortex. Necessary for proper development of megakaryocytes and platelets and for bone marrow B-lymphopoiesis. Required for B-cell survival and proliferation in response to BCR stimulation, efficient IgG1 antibody responses to T-cell-dependent antigens and for normal induction of germinal center B-cells. May also be involved in neurogenesis and in the development of cortical architecture (By similarity). Isoform 3 and isoform 4, which lack the repressor domain, are more active than isoform 1 and isoform 2.

Gene Name: myocyte enhancer factor 2C
Synonyms: MEF2C, C5DELq14.3, DEL5q14.3, Myocyte enhancer factor 2C
Target Sequences: NM_002397 NP_002388.2 Q06413

Publications (2)

1
Lymphoangiocrine signals promote cardiac growth and repair. Xiaolei Liu, Ester De la Cruz, Xiaowu Gu, Laszlo Balint, Michael Oxendine-Burns, Tamara Terrones, Wanshu Ma, Hui-Hsuan Kuo, Connor Lantz, Trisha Bansal, Edward Thorp, Paul Burridge, Zoltán Jakus, Joachim Herz, Ondine Cleaver, Miguel Torres, Guillermo Oliver. Nature. 2020 December; [Full Text Article] [PubMed:33299187] [PMC:PMC7770123] Related Antibodies: LS-C356188.
2
Downregulated miR-18b-5p triggers apoptosis by inhibition of calcium signaling and neuronal cell differentiation in transgenic SOD1 (G93A) mice and SOD1 (G17S and G86S) ALS patients. Ki Yoon Kim, Yu Ri Kim, Kyung Won Choi, Mijung Lee, Somyung Lee, Wooseok Im, Je-Young Shin, Jin Young Kim, Yoon Ho Hong, Manho Kim, Jong-Il Kim, Jung-Joon Sung. Translational neurodegeneration. 2020 July;9:23. [Full Text Article] [PubMed:32605607] [PMC:PMC7328278] Related Antibodies: LS-C31031.

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Antibodies (129)
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MEF2C (139)
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MEF2C Antibody - Immunohistochemical analysis of MEF2C staining in human lung cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
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MEF2C Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Zebrafish, Pig, Mouse, Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$299
MEF2C Antibody - SP2/0 Cell Lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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MEF2C Rabbit anti-Mouse Polyclonal (aa78-127) Antibody
Mouse, Human
WB
Unconjugated
100 µl/$397
MEF2C Antibody - IHC of paraffin-embedded Human Ovary tissue using anti-MEF2C mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min).
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MEF2C Mouse anti-Human Monoclonal (OTI1H5) Antibody
Human
Flo, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$434
MEF2C Antibody - IHC of paraffin-embedded Human Ovary tissue using anti-MEF2C mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min).
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MEF2C Mouse anti-Human Monoclonal (Carrier-free) (OTI1H5) Antibody
Human
Flo, IF, IHC, WB
Unconjugated, Carrier-free
100 µg/$511
MEF2C Antibody - Anti-MEF2C antibody IHC of human adrenal. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
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MEF2C Rabbit anti-Human Polyclonal (Ser59) Antibody
Human
IHC, IHC-P, WB
Unconjugated
200 µl/$460
MEF2C Antibody - IHC of paraffin-embedded colon cancer tissues using MEF2C mouse monoclonal antibody with DAB staining.
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MEF2C Mouse anti-Human Monoclonal (6H2G2) Antibody
Human
ELISA, Flo, IHC, IHC-P, WB
Unconjugated
100 µl/$459
MEF2C Antibody - Anti-MEF2C mouse monoclonal antibody immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY MEF2C.
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MEF2C Mouse anti-Human Monoclonal (OTI4B10) Antibody
Human
Flo, IF, WB
Unconjugated
100 µl/$434
MEF2C ELISA Kit
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DNA Binding Phosphorylation
12 x 8-Well Microstrips
Mouse, Human
Colorimetric - 450nm (TMB)
Cell Lysates, Nuclear Lysates
1 Plate/$735
MEF2C Antibody - Immunohistochemistry analysis of paraffin-embedded human brain, using MEF2C (Phospho-Ser396) Antibody. The picture on the right is blocked with the phospho peptide.
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MEF2C Rabbit anti-Human Polyclonal (pSer396) Antibody
Mouse, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
MEF2C Antibody - Formalin-fixed and paraffin-embedded human brain tissue reacted with MEF2C Antibody (T300), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
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MEF2C Rabbit anti-Human Polyclonal (Thr300) Antibody
Human
IHC, IHC-P, WB
Unconjugated
400 µl/$393
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MEF2C Rabbit anti-Human Polyclonal (Ser387) (PE) Antibody
Human
ELISA, IHC, WB
PE Conjugated
200 µl/$952
MEF2C Antibody - Immunofluorescence analysis of U2OS cells.
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MEF2C Rabbit anti-Human Polyclonal (pSer396) Antibody
IF, WB
Unconjugated
20 µl/$287; 50 µl/$341; 100 µl/$431; 200 µl/$539
MEF2C Antibody - IHC of paraffin-embedded Adenocarcinoma of Human colon tissue using anti-MEF2C mouse monoclonal antibody.
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MEF2C Mouse anti-Human Monoclonal (OTI4F7) Antibody
Human
Flo, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$434
MEF2C Antibody - IHC of paraffin-embedded Adenocarcinoma of Human colon tissue using anti-MEF2C mouse monoclonal antibody.
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MEF2C Mouse anti-Human Monoclonal (Carrier-free) (OTI4F7) Antibody
Human
Flo, IF, IHC, WB
Unconjugated, Carrier-free
100 µg/$511
MEF2C Antibody - IHC of paraffin-embedded Human breast tissue using anti-MEF2C mouse monoclonal antibody.
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MEF2C Mouse anti-Human Monoclonal (OTI1B6) Antibody
Human
Flo, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$434
MEF2C Antibody - IHC of paraffin-embedded Human breast tissue using anti-MEF2C mouse monoclonal antibody.
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MEF2C Mouse anti-Human Monoclonal (Carrier-free) (OTI1B6) Antibody
Human
Flo, IF, IHC, WB
Unconjugated, Carrier-free
100 µg/$511
MEF2C Antibody - IHC of paraffin-embedded Human Ovary tissue using anti-MEF2C mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min).
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MEF2C Mouse anti-Human Monoclonal (OTI2D2) Antibody
Human
Flo, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$434
MEF2C Antibody - IHC of paraffin-embedded Human Ovary tissue using anti-MEF2C mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min).
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MEF2C Mouse anti-Human Monoclonal (Carrier-free) (OTI2D2) Antibody
Human
Flo, IF, IHC, WB
Unconjugated, Carrier-free
100 µg/$511
MEF2C Antibody - IHC of paraffin-embedded Adenocarcinoma of Human colon tissue using anti-MEF2C mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min).
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MEF2C Mouse anti-Human Monoclonal (OTI4G8) Antibody
Human
Flo, IHC, IHC-P, WB
Unconjugated
100 µl/$434
MEF2C Antibody - IHC of paraffin-embedded Adenocarcinoma of Human colon tissue using anti-MEF2C mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min).
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MEF2C Mouse anti-Human Monoclonal (Carrier-free) (OTI4G8) Antibody
Human
Flo, IHC, WB
Unconjugated, Carrier-free
100 µg/$511
MEF2C Antibody - Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE)
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MEF2C Rabbit anti-Human Polyclonal (aa362-411) Antibody
Mouse, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
100 µl/$515
MEF2C Antibody - Western blot of LEG9 expression in HepG2 cells
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MEF2C Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ICC, IF, IHC, WB
Unconjugated
50 µg/$305; 100 µg/$357
MEF2C Antibody - Formalin-fixed and paraffin-embedded human brain tissue reacted with MEF2C Antibody (S387) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
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MEF2C Rabbit anti-Human Polyclonal (Ser387) Antibody
Human
IF, IHC, IHC-P, WB
Unconjugated
400 µl/$393
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MEF2C Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, IP, WB
Unconjugated
100 µg/$331
MEF2C Antibody - MEF2C Antibody in Immunohistochemistry (IHC)
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MEF2C Mouse anti-Human Monoclonal (Amino Acid: 1-125) (6H2G2) Antibody
Mouse, Rat, Human
Flo, IHC, WB
Unconjugated
100 µg/$503
Viewing 1-25 of 139 product results



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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).