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Anti-MDM4 / MDMX Antibody (aa128-157) LS-C164109

Catalog	Size	Price
LS-C164109-400	400 µl	Unavailable

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Details

Target:	Human MDM4 / MDMX
Host:	Rabbit
Reactivity:	Human (tested or 100% immunogen sequence identity)
Clonality:	Polyclonal
Conjugations:	Unconjugated
Purification:	Protein A purified
Modifications:	Unmodified

Applications

Approved:

Western blot (1:1000)

Specificity and Use

Blocking Peptide:

LS-E2764 - Lyophilized - 100 µg - $145.00
Immunizing peptide used to generate LS-C164109. Useful for pre-absorption and neutralization of the antibody's antigen binding site.

Epitope:

aa128-157

Specificity:

This MDM4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 128-157 amino acids from the Central region of human MDM4.

Packaging

Presentation:	PBS, 0.09% sodium azide
Storage:	Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
Restrictions:	For research use only.

About MDM4 / MDMX

Uniprot: O15151 NCBI: NM_002393 NP_002384.2

Synonyms: MDM4 Antibody, Mdm2-like p53-binding protein Antibody, MDMX Antibody, HDMX Antibody, MRP1 Antibody, p53-binding protein Mdm4 Antibody, Protein Mdm4 Antibody, Double minute 4 protein Antibody, MDM4-related protein 1 Antibody, Protein Mdmx Antibody

Description: MDM4 / MDMX is a nuclear protein that contains a p53 binding domain at the N-terminus and a RING finger domain at the C-terminus, and shows structural similarity to p53-binding protein MDM2. Both proteins bind the p53 tumor suppressor protein and inhibit its activity, and have been shown to be overexpressed in a variety of human cancers. However, unlike MDM2 which degrades p53, this protein inhibits p53 by binding its transcriptional activation domain.

(More About MDM4 / MDMX)

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Technical Help Review

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Western blot

MDM4 Antibody western blot of ZR-75-1 cell line lysates (35 ug/lane). The MDM4 antibody detected the MDM4 protein (arrow).

Requested From:
Date Requested: 6/22/2017

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