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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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MDM4 / MDMX Antibody (aa125‑175) LS‑C67243
Antibody
MDMX antibody LS-C67243 is an unconjugated rabbit polyclonal antibody to human MDMX (MDM4). Validated for Flow, IP and WB.
Catalog
Size
Price
LS-C67243-100
100 µg
Unavailable

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Product Description

MDMX antibody LS-C67243 is an unconjugated rabbit polyclonal antibody to human MDMX (MDM4). Validated for Flow, IP and WB.
About MDM4 / MDMX
MDM4 / MDMX is a nuclear protein that contains a p53 binding domain at the N-terminus and a RING finger domain at the C-terminus, and shows structural similarity to p53-binding protein MDM2. Both proteins bind the p53 tumor suppressor protein and inhibit its activity, and have been shown to be overexpressed in a variety of human cancers. However, unlike MDM2 which degrades p53, this protein inhibits p53 by binding its transcriptional activation domain. O15151 NM_002393 NP_002384.2

MDM4 Antibody, Mdm2-like p53-binding protein Antibody, MDMX Antibody, HDMX Antibody, MRP1 Antibody, p53-binding protein Mdm4 Antibody, Protein Mdm4 Antibody, Double minute 4 protein Antibody, MDM4-related protein 1 Antibody, Protein Mdmx Antibody


Specifications

Target
Human MDM4 / MDMX
Host
Rabbit
Reactivity
Human (tested or 100% immunogen sequence identity)
Clonality
Polyclonal
Conjugations
Unconjugated
Purification
Immunoaffinity purified
Modifications
Unmodified
Applications
  • Western blot (1:10000 - 1:25000)
  • Immunoprecipitation
  • Flow Cytometry
Immunogen
MDM4 / MDMX antibody was raised against a synthetic peptide which maps to a region between residues 125 and 175 of human ortholog of mouse double minute 4 using the numbering given in Swiss-Prot entry O15151 (GeneID 4194).
Epitope
aa125-175
Specificity
Specific for human HdmX/MDM4 protein. Other species not tested. Reactivity with mouse MdmX is unlikely owing to divergence of sequence between MdmX and HdmX/MDM4 at the site to which the epitope maps.
Usage
Suitable for use in Flow Cytometry, Western Blot and Immunoprecipitation. Immunoprecipitation: 2-5 ug/mg lysate. Western Blot: 1:10000-1:25000.
Presentation
Tris-citrate/phosphate buffer, pH 7.5, 0.09% sodium azide.
Restrictions
For research use only.
Guarantee
This antibody carries the LSBio 100% Guarantee.

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Requested From: 
Date Requested: 6/25/2018

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