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Anti-MDM2 Antibody (aa393-424) LS-C98807

Catalog Size Price
LS-C98807-400 400 µl Unavailable

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129 MDM2 Antibodies

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HEK293 overexpressing MDM2 (RC219518) and probed with (mock transfection in first lane).
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100% Guaranteed
Rabbit Polyclonal to Human MDM2
Human, Mouse
IHC, IHC - Paraffin, Western blot
Unconjugated

Details

Human MDM2
Rabbit
Human, Mouse (tested or 100% immunogen sequence identity)
Polyclonal
Unconjugated
Ammonium sulfate precipitation
Unmodified

Applications

  • IHC
  • IHC - Paraffin (1:10 - 1:50)
  • Western blot (1:1000)

  • IHC - Paraffin

Specificity and Use

LS-E1757 - Lyophilized - 100 µg - $145.00
Immunizing peptide used to generate LS-C98807. Useful for pre-absorption and neutralization of the antibody's antigen binding site.
aa393-424
This Mdm2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 393-424 amino acids from the C-terminal region of human Mdm2.

Packaging

PBS, 0.09% sodium azide
Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
For research use only.

About MDM2

Q00987 NM_002392 NP_002383.2

MDM2 Antibody, ACTFS Antibody, Double minute 2 protein Antibody, Hdm2 Antibody, MDM2 variant FB30 Antibody, HDMX Antibody, Oncoprotein Mdm2 Antibody, p53-binding protein Mdm2 Antibody, MDM2 variant FB28 Antibody

E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome. Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Also acts as a ubiquitin ligase E3 toward itself and ARRB1. Permits the nuclear export of p53/TP53. Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein.

Immunohistochemistry

Mdm2 Antibody immunohistochemistry of formalin-fixed and paraffin-embedded human prostate carcinoma followed by peroxidase-conjugated secondary antibody and DAB staining.
Mdm2 Antibody immunohistochemistry of formalin-fixed and paraffin-embedded human prostate carcinoma followed by peroxidase-conjugated secondary antibody and DAB staining.

Western blot

Western blot of MDM2 (arrow) using rabbit polyclonal Mdm2 Antibody. 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the MDM2 gene (Lane 2) (Origene Technologies).
Western blot of MDM2 (arrow) using rabbit polyclonal Mdm2 Antibody. 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the MDM2 gene (Lane 2) (Origene Technologies).

Western blot

MDM2 Antibody (Q213) western blot of HepG2 cell line lysates (35 ug/lane). The MDM2 antibody detected the MDM2 protein (arrow).
MDM2 Antibody (Q213) western blot of HepG2 cell line lysates (35 ug/lane). The MDM2 antibody detected the MDM2 protein (arrow).

Western blot

Western blot of anti-Mdm2 antibody in mouse lung tissue lysate. Mdm2 (Arrow) was detected using purified antibody. Secondary HRP-anti-rabbit was used for signal visualization with chemiluminescence.
Western blot of anti-Mdm2 antibody in mouse lung tissue lysate. Mdm2 (Arrow) was detected using purified antibody. Secondary HRP-anti-rabbit was used for signal visualization with chemiluminescence.

Requested From: 
Date Requested: 4/26/2018

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