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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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MDM2 Antibody (aa18‑22) LS‑C205103
MDM2 antibody LS-C205103 is an unconjugated rabbit polyclonal antibody to human MDM2. Validated for WB.
Catalog
Size
Price
LS-C205103-50
50 µg (1 mg/ml)
Unavailable

Popular MDM2 Products

Antibody
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Product Description

MDM2 antibody LS-C205103 is an unconjugated rabbit polyclonal antibody to human MDM2. Validated for WB.
About MDM2
E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome. Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Also acts as a ubiquitin ligase E3 toward itself and ARRB1. Permits the nuclear export of p53/TP53. Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein. Q00987 NM_002392 NP_002383.2

MDM2 Antibody, ACTFS Antibody, Double minute 2 protein Antibody, Hdm2 Antibody, MDM2 variant FB30 Antibody, HDMX Antibody, Oncoprotein Mdm2 Antibody, p53-binding protein Mdm2 Antibody, MDM2 variant FB28 Antibody


Specifications

Target
Human MDM2
Host
Rabbit
Reactivity
Human (tested or 100% immunogen sequence identity)
Clonality
Polyclonal
Conjugations
Unconjugated
Purification
Immunoaffinity purified
Modifications
Unmodified
Applications
  • Western blot (1:500 - 1:1000)
Immunogen
MDM2 antibody was raised against peptide sequence around amino acids 18-22 (Q-I-P-A-S) of human MDM2.
Epitope
aa18-22
Specificity
The antibody detects endogenous levels of total MDM2 protein.
Presentation
PBS, pH 7.4, 0.02% sodium azide, 50% glycerol.
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Restrictions
For research use only.
Guarantee
This antibody carries the LSBio 100% Guarantee.

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Images


Western blot

Western blot of extracts from 293 and HeLa cells using MDM2 antibody.
Western blot of extracts from 293 and HeLa cells using MDM2 antibody.

Western blot

Western blot of extracts from 293 and HeLa cells using MDM2 antibody.
Western blot of extracts from 293 and HeLa cells using MDM2 antibody.

Western blot

Western blot of extracts from 293 and HeLa cells using MDM2 antibody.
Western blot of extracts from 293 and HeLa cells using MDM2 antibody.

Western blot

Western blot of extracts from 293 and HeLa cells using MDM2 antibody.
Western blot of extracts from 293 and HeLa cells using MDM2 antibody.


Requested From: 
Date Requested: 6/22/2018

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