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Anti-MDM2 Antibody (aa177-195) LS-C42649

Ordering

Wt. Vol. Conc. Price
50 µg - 0.5 mg/ml $350
Inquire for larger quantities

LSBio (Direct) LSBio (Direct)
206-374-1102
866-206-6909
Orders@LSBio.com
 

Most Popular MDM2 Antibodies

Anti-MDM2 Antibody (aa154-167, clone SMP14) IHC-plus™ LS-B163
Mouse Monoclonal [clone SMP14] (IgG1) to Human MDM2
Human, Monkey, Rat, Dog
IHC - Paraffin, IHC - Frozen, IHC - Resin, Immunoprecipitation
Unconjugated
Immunohistochemistry Image
Anti-MDM2 Antibody (clone 1A7) IHC-plus™ LS-B5461
Mouse Monoclonal [clone 1A7] (IgG1,k) to Human MDM2
Human
IHC - Paraffin, Western blot, ELISA
Unconjugated
Immunohistochemistry Image
Anti-MDM2 Antibody (Internal) LS-C209837
Rabbit Polyclonal (IgG) to Zebrafish MDM2
Zebrafish
IHC, Western blot, ELISA
Unconjugated
Immunohistochemistry Image

100% Guaranteed 100% Guaranteed
Rabbit Polyclonal (IgG) to Mouse MDM2
Mouse
Western blot, ELISA
Unconjugated

Details

Mouse MDM2
Rabbit
Mouse (tested or 100% immunogen sequence identity)
IgG Polyclonal
Unconjugated
Purified IgG
Unmodified

Applications

  • Western blot (1:500 - 1:2000)
  • ELISA (1:3000 - 1:12000)

Specificity and Use

MDM2 antibody was raised against synthetic peptide corresponding to aa 177-195 of mouse Mdm2.
aa177-195
Detects murine Mdm2, a nuclear phosphoprotein that controls intracellular levels of the tumor suppressor protein p53 by ubiquitination and subsequent proteasomal degradation. Mdm2 also interacts with the retinoblastoma (RB) protein and E2F-1, to promote G1-S phase transition in the cell cycle. Mdm2 activity is controlled by self-ubiquitination; however activation of the PI3K/PKB pathway leads to phosphorylation of Mdm2 at Ser185, which stabilizes the protein.
Western Blot: LS-C42649 detects a band of approximately 90kD in mouse MEF cell lysates.

Packaging

PBS, pH 7.2, 0.01% sodium azide.
+4°C or -20°C, Avoid repeated freezing and thawing.
For research use only.

About MDM2

Q00987 NM_002392 NP_002383.2

MDM2 Antibody, ACTFS Antibody, Double minute 2 protein Antibody, Hdm2 Antibody, MDM2 variant FB30 Antibody, HDMX Antibody, Oncoprotein Mdm2 Antibody, p53-binding protein Mdm2 Antibody, MDM2 variant FB28 Antibody

E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome. Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Also acts as a ubiquitin ligase E3 toward itself and ARRB1. Permits the nuclear export of p53/TP53. Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein.

Requested From: United States
Date Requested: 12/9/2016

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