MDC1

mediator of DNA-damage checkpoint 1

Required for checkpoint mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle. May serve as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage marked by 'Ser-139' phosphorylation of histone H2AFX. Also required for downstream events subsequent to the recruitment of these proteins. These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53 and apoptosis. ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1.

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Products

Antibodies (38)

Proteins (2)

Type

Primary (38)

Recombinant (2)

Target

MDC1 (40)

Reactivity

Human (37)

Mouse (14)

Rat (1)

Bovine (11)

Chimpanzee (3)

Dog (3)

Monkey (1)

Pig (3)

Application

IHC (17)

IHC-P (8)

WB (27)

ELISA (10)

ICC (1)

IF (10)

IP (4)

Peptide-ELISA (2)

Host

rabbit (27)

mouse (11)

Product Group

IHCPlus (1)

Isotype

IgG (21)

IgG1 (11)

Clonality

monoclonal mc (11)

polyclonal pc (27)

Clone

P2B11 (11)

Format

AP Conjugated (1)

APC Conjugated (1)

Atto 390 Conjugated (1)

Atto 488 Conjugated (1)

Atto 594 Conjugated (1)

Biotin Conjugated (3)

FITC Conjugated (3)

HRP Conjugated (2)

PerCP Conjugated (1)

RPE Conjugated (1)

Unconjugated (23)

more less

Epitope

N-Terminus (9)

aa1851-1900 (4)

aa1375-1425 (2)

pSer513 (2)

450-530 aa (1)

aa475-525 (1)

aa871-888 (1)

aa900-950 (1)

aa925-975 (1)

Publications

No (40)

Tag

6His, N-terminus (1)

6His-SUMO, N-terminus (1)

Species

Human (2)

Source

E. coli (1)

Yeast (1)

Purification

Purified (2)

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MDC1 Antibody (clone P2B11) LS-C152962

Antibody:

MDC1 Mouse anti-Human Monoclonal (P2B11) Antibody

Reactivity:

Mouse, Bovine, Human

Applications:

ICC, WB

Format:

Unconjugated

Price:

100 µg/$531

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MDC1 Antibody (aa1851-1900) LS-B10226

Antibody:

MDC1 Rabbit anti-Human Polyclonal (aa1851-1900) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$485

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MDC1 Antibody LS-C409894

Antibody:

MDC1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

IHC, WB

Format:

Unconjugated

Price:

20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503

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MDC1 Antibody LS-C662710

Antibody:

MDC1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-P

Format:

Unconjugated

Price:

10 µg/$318; 100 µg/$470

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MDC1 Antibody LS-C751757

Antibody:

MDC1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

100 µg/$351

Select

MDC1 Antibody (clone P2B11) LS-C150396

Antibody:

MDC1 Mouse anti-Human Monoclonal (P2B11) Antibody

Reactivity:

Mouse, Bovine, Human

Applications:

IF, WB

Format:

Unconjugated

Price:

100 µg/$425

Select

MDC1 Antibody (N-Terminus, clone P2B11, Biotin) LS-C231462

Antibody:

MDC1 Mouse anti-Mouse Monoclonal (N-Terminus) (Biotin) (P2B11) Antibody

Reactivity:

Mouse, Bovine, Human

Applications:

IF, WB

Format:

Biotin Conjugated

Price:

100 µg/$458

Select

MDC1 Antibody (N-Terminus, clone P2B11, FITC) LS-C231464

Antibody:

MDC1 Mouse anti-Mouse Monoclonal (N-Terminus) (FITC) (P2B11) Antibody

Reactivity:

Mouse, Bovine, Human

Applications:

IF, WB

Format:

FITC Conjugated

Price:

100 µg/$456

Select

MDC1 Antibody (N-Terminus, clone P2B11, Atto 488) LS-C231452

Antibody:

MDC1 Mouse anti-Mouse Monoclonal (N-Terminus) (Atto 488) (P2B11) Antibody

Reactivity:

Mouse, Bovine, Human

Applications:

IF, WB

Format:

Atto 488 Conjugated

Price:

100 µg/$462

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MDC1 Antibody (N-Terminus, clone P2B11, Atto 390) LS-C231453

Antibody:

MDC1 Mouse anti-Mouse Monoclonal (N-Terminus) (Atto 390) (P2B11) Antibody

Reactivity:

Mouse, Bovine, Human

Applications:

IF, WB

Format:

Atto 390 Conjugated

Price:

100 µg/$463

Select

MDC1 Antibody (N-Terminus, clone P2B11, Atto 594) LS-C231454

Antibody:

MDC1 Mouse anti-Mouse Monoclonal (N-Terminus) (Atto 594) (P2B11) Antibody

Reactivity:

Mouse, Bovine, Human

Applications:

IF, WB

Format:

Atto 594 Conjugated

Price:

100 µg/$462

Select

MDC1 Antibody (N-Terminus, clone P2B11, AP) LS-C231460

Antibody:

MDC1 Mouse anti-Mouse Monoclonal (N-Terminus) (AP) (P2B11) Antibody

Reactivity:

Mouse, Bovine, Human

Applications:

IF, WB

Format:

AP Conjugated

Price:

100 µg/$457

Select

MDC1 Antibody (N-Terminus, clone P2B11, PerCP) LS-C231466

Antibody:

MDC1 Mouse anti-Mouse Monoclonal (N-Terminus) (PerCP) (P2B11) Antibody

Reactivity:

Mouse, Bovine, Human

Applications:

IF, WB

Format:

PerCP Conjugated

Price:

100 µg/$461

Select

MDC1 Antibody (N-Terminus, clone P2B11, APC) LS-C231461

Antibody:

MDC1 Mouse anti-Mouse Monoclonal (N-Terminus) (APC) (P2B11) Antibody

Reactivity:

Mouse, Bovine, Human

Applications:

IF, WB

Format:

APC Conjugated

Price:

100 µg/$461

Select

MDC1 Antibody (N-Terminus, clone P2B11, RPE) LS-C231467

Antibody:

MDC1 Mouse anti-Mouse Monoclonal (N-Terminus) (RPE) (P2B11) Antibody

Reactivity:

Mouse, Bovine, Human

Applications:

IF, WB

Format:

RPE Conjugated

Price:

100 µg/$459

• Unconjugated
• Biotin
• FITC
• Atto 488
• Atto 390
• Atto 594
• AP
• More...
  • PerCP
  • APC
  • RPE

• Unconjugated
• Biotin
• FITC
• More...
  • Atto 488
  • Atto 390
  • Atto 594
  • AP
  • PerCP
  • APC
  • RPE

Select

MDC1 Antibody (aa1375-1425) LS-C286994

Antibody:

MDC1 Rabbit anti-Human Polyclonal (aa1375-1425) Antibody

Reactivity:

Human

Applications:

IHC, IP, WB

Format:

Unconjugated

Price:

10 µl/$295; 100 µl/$514

Select

MDC1 Antibody (aa925-975) LS-C286993

Antibody:

MDC1 Rabbit anti-Human Polyclonal (aa925-975) Antibody

Reactivity:

Human

Applications:

IHC, IP, WB

Format:

Unconjugated

Price:

100 µl/$514

Select

MDC1 Antibody LS-C155197

Antibody:

MDC1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$450

Select

MDC1 Antibody LS-C668488

Antibody:

MDC1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µl/$286; 100 µl/$321

Select

MDC1 Antibody (450-530 aa) LS-C381688

Antibody:

MDC1 Rabbit anti-Human Polyclonal (450-530 aa) Antibody

Reactivity:

Human

Applications:

ELISA, IHC

Format:

Unconjugated

Price:

50 µg/$295; 100 µg/$335; 200 µg/$394

Select

MDC1 Antibody (phospho-Ser513) LS-C199237

Antibody:

MDC1 Rabbit anti-Human Polyclonal (pSer513) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, Peptide-ELISA

Format:

Unconjugated

Price:

50 µl/$334; 100 µl/$397

Select

MDC1 Antibody LS-C768093

Antibody:

MDC1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

IHC, WB

Format:

Unconjugated

Price:

60 µl/$331; 120 µl/$403; 200 µl/$529

Select

MDC1 Antibody LS-C402706

Antibody:

MDC1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC

Format:

Unconjugated

Price:

20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450

Select

MDC1 Antibody (phospho-Ser513) LS-C827094

Antibody:

MDC1 Rabbit anti-Human Polyclonal (pSer513) Antibody

Reactivity:

Human

Applications:

ELISA, IHC

Format:

Unconjugated

Price:

100 µg/$357

Select

MDC1 Antibody LS-C19019

Antibody:

MDC1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µg/$567

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