Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Role for Plk1 phosphorylation of Hbo1 in regulation of replication licensing. Wu ZQ, Liu X. Proceedings of the National Academy of Sciences of the United States of America. 2008 105:1919-24.
Plk1 phosphorylation of Orc2 promotes DNA replication under conditions of stress. Song B, Liu XS, Davis K, Liu X. Molecular and cellular biology. 2011 31:4844-56.
Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit.
Immunofluorescent microscope analysis of Hela cells using anti-MCM2 polyclonal antibody (poly6022) (red). a-tubulin (clone 10D8) has been labeled with green and nuclei were stain with DAPI (blue).
Hela cell nuclear extract was resolved by electrophoresis, transferred to nitrocellulose and probed with rabbit anti-MCM2 antibody. Proteins were visualized using a donkey anti-rabbit secondary antibody conjugated to HRP and a chemiluminescence system.
Requested From: United States
Date Requested: 10/23/2016