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MCL1 / MCL 1
myeloid cell leukemia sequence 1 (BCL2-related)
Myeloid cell leukimia-1 (Mcl-1) is a member of the Bcl-2 family of proteins that can act to promote cell survival. While the mechanism by which Mcl-1 inhibits apoptosis is not known, it is thought that it may heterodimerize and neutralize pro-apoptotic members of the Bcl-2 family such as Bim or Bak. Mcl-1 was originally identified in differentiating myeloid cells, but has since been shown to be expressed in multiple cell types. Mcl-1 is essential for embryogenesis (5) and for the development and maintenance of B and T lymphocytes in animals. Mcl-1 exists as at least two distinct isoforms designated Mcl-1L and Mcl-1S. In marked contrast to the larger isoform of Mcl-1, overexpression of Mcl-1S promotes cell death.
| Gene Name: | myeloid cell leukemia sequence 1 (BCL2-related) |
| Synonyms: | MCL1, BCL2L3, Bcl-2-like protein 3, Bcl-2-related protein EAT/mcl1, Bcl2-L-3, MCL1S, MCL1L, Myeloid cell leukemia ES, MCL 1, MCL1-ES, TM, EAT, Mcl-1 |
| Target Sequences: | NM_021960 NP_068779.1 Q07820 |
Publications (5)
1
Glycogen synthase kinase 3alpha and 3beta mediate a glucose-sensitive antiapoptotic signaling pathway to stabilize Mcl-1. Zhao Y, Altman BJ, Coloff JL, Herman CE, Jacobs SR, Wieman HL, Wofford JA, Dimascio LN, Ilkayeva O, Kelekar A, Reya T, Rathmell JC. Molecular and cellular biology. 2007 27:4328-39.
[PubMed:17371841]
[PMC:PMC1900055]
2
Concurrent up-regulation of BCL-XL and BCL2A1 induces approximately 1000-fold resistance to ABT-737 in chronic lymphocytic leukemia. Vogler M, Butterworth M, Majid A, Walewska RJ, Sun XM, Dyer MJ, Cohen GM. Blood. 2009 113:4403-13. (IP)
[PubMed:19008458]
3
The Pim kinase pathway contributes to survival signaling in primed CD8+ T cells upon CD27 costimulation. Peperzak V, Veraar EA, Keller AM, Xiao Y, Borst J. Journal of immunology (Baltimore, Md. : 1950). 2010 185:6670-8.
[PubMed:21048108]
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Target
MCL1 / MCL 1
(145)
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(119)
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(60)
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(29)
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(1)
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(5)
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(1)
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(5)
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(4)
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(68)
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(1)
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Publications
No
(145)
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(1)
MCL1 / MCL 1 Mouse anti-Human Monoclonal (2E11) Antibody
Human
Flo, IF, IHC, IHC-P, WB
Unconjugated
50 µl/$460
MCL1 / MCL 1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, ICC, IF, IHC, IHC-P, WB
Unconjugated
0.05 mg/$460
MCL1 / MCL 1 Mouse anti-Human Monoclonal (8C6D4B1) Antibody
Human
ELISA, IF, IHC, IHC-Fr, IHC-P, WB
Unconjugated
50 µl/$460
E. coli
His, N-Terminal
36.6 kDa
10 µg/$284; 50 µg/$460; 100 µg/$735; 200 µg/$917; 1 mg/$2,037; 500 µg/$1,571; 5 mg/$3,207; 2 mg/$2,225
Sandwich
96-Well Strip Plate
Human
1.56 - 100 U/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$783
Sandwich
96-Well Strip Plate
Human
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$834
E. coli
His
50 µg/$411; 250 µg/$985; 10 µg/$276
MCL1 / MCL 1 Mouse anti-Human Monoclonal (8C6D4B1) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$440
MCL1 / MCL 1 Rabbit anti-Human Polyclonal (aa217-245) Antibody
Human
IHC, IHC-P, WB
Unconjugated
400 µl/$393
MCL1 / MCL 1 Mouse anti-Human Monoclonal (OTI10D10) Antibody
Human
Flo, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$434
MCL1 / MCL 1 Mouse anti-Human Monoclonal (OTI10F6) Antibody
Human
Flo, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$434
MCL1 / MCL 1 Rabbit anti-Human Polyclonal (aa121-139) Antibody
Human
IHC, IHC-P
Unconjugated
250 µl/$495
MCL1 / MCL 1 Rabbit anti-Human Polyclonal (aa191-226) (Biotin) Antibody
Mouse, Human
ELISA, Flo, IHC, WB
Biotin Conjugated
200 µl/$952
MCL1 / MCL 1 Rabbit anti-Human Polyclonal (aa191-226) (FITC) Antibody
Mouse, Human
ELISA, Flo, IHC, WB
FITC Conjugated
200 µl/$952
MCL1 / MCL 1 Rabbit anti-Human Polyclonal (aa191-226) (APC) Antibody
Mouse, Human
ELISA, Flo, IHC, WB
APC Conjugated
200 µl/$952
MCL1 / MCL 1 Rabbit anti-Human Polyclonal Antibody
Rabbit, Dog, Guinea pig, Human, Monkey
IF, IHC, IHC-P, WB
Unconjugated
50 µg/$485
MCL1 / MCL 1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, ICC, WB
Unconjugated
0.1 mg/$460
MCL1 / MCL 1 Mouse anti-Human Monoclonal (MCL.C9) Antibody
Human
ELISA, WB
Unconjugated
100 µg/$352
MCL1 / MCL 1 Mouse anti-Human Monoclonal (10C5) Antibody
Human
IF, IHC, IHC-P, WB
Unconjugated
100 µl/$485
MCL1 / MCL 1 Rabbit anti-Human Monoclonal Antibody
Mouse, Rat, Human
Flo, IF, IHC, IP, WB
Unconjugated
20 µl/$299; 50 µl/$341; 100 µl/$431; 200 µl/$539
MCL1 / MCL 1 Rabbit anti-Human Polyclonal (aa6-328) (APC, Cy7) Antibody
Human
WB
APC, Cy7 Conjugated
100 µl/$505; 200 µl/$648; 500 µl/$1,152; 1 ml/$1,401; 2 ml/$1,961; 5 ml/$3,676
MCL1 / MCL 1 Mouse anti-Human Monoclonal Antibody
Human
ELISA, IHC, IHC-Fr, IHC-P, IP, WB
Unconjugated
100 µl/$872
E. coli
His-T7
38.4 kDa
10 µg/$279; 50 µg/$432; 100 µg/$690; 200 µg/$862; 1 mg/$1,962; 500 µg/$1,505; 5 mg/$3,011; 2 mg/$2,148
Sandwich
96-Well Strip Plate
Human
0.16 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$651
MCL1 / MCL 1 Rabbit anti-Human Polyclonal (aa91-140) Antibody
Mouse, Rat, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
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