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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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MCL1 / MCL 1 Antibody LS‑C8942
MCL 1 antibody LS-C8942 is an unconjugated mouse monoclonal antibody to human MCL 1 (MCL1). Validated for ELISA, IHC, IP and WB.
Antibody
Catalog
Size
Price
LS-C8942-100
100 µg (0.2 mg/ml)
$605

Popular MCL1 / MCL 1 Products

Anti-MCL1 / MCL 1 antibody IHC staining of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
Species: Human
Applications: IHC, IHC - Paraffin, Immunofluorescence, Western blot, Flow Cytometry
Anti-MCL1 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 2 ug/ml.
Species: Human, Mouse, Rat
Applications: IHC, IHC - Paraffin, ICC, Immunofluorescence, Western blot
IHC of paraffin-embedded human lymph node showing cytoplasmic localization using MCL-1 antibody with DAB staining.
Species: Human
Applications: IHC, IHC - Paraffin, IHC - Frozen, Western blot, ELISA
Antibody
Species: Human, Mouse
Applications: IHC, Western blot, Flow Cytometry, ELISA
Anti-MCL1 antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:25.
Species: Human
Applications: IHC, IHC - Paraffin

Product Description

MCL 1 antibody LS-C8942 is an unconjugated mouse monoclonal antibody to human MCL 1 (MCL1). Validated for ELISA, IHC, IP and WB.

Specifications

Target
Human MCL1 / MCL 1
Synonyms
MCL1, BCL2L3, Bcl-2-like protein 3, Bcl-2-related protein EAT/mcl1, Bcl2-L-3, MCL1S, MCL1L, Myeloid cell leukemia ES, MCL 1, MCL1-ES, TM, EAT, Mcl-1
Host
Mouse
Reactivity
Human (tested or 100% immunogen sequence identity)
Clonality
IgG1 Monoclonal
Conjugations
Unconjugated. Also available conjugated with AP, APC, Biotin, FITC, HRP, PE.
Purification
Protein G purified
Modifications
Unmodified
Applications
  • IHC
  • IHC - Paraffin
  • IHC - Frozen
  • Western blot (1:100 - 1:200)
  • Immunoprecipitation (1:100 - 1:200)
  • ELISA
  • (applications tested for the base form of this product only)
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Immunogen
MCL1 / MCL 1 antibody was raised against recombinant human Mcl-1 protein corresponding to amino acid 1-327.
Specificity
Recognizes human Mcl-1 (Myeloid cell leukemia-1) (MW 42kD).
Usage
Suitable for use in ELISA, Western Blot, Immunoprecipitation, Immunohistochemistry. Western Blot: 1:100-1:200. Immunoprecipitation: 10 ul/mg of cell lysate. Immunohistochemistry: (with cryostat or formalin-fixed paraffin embedded sections). Staining of formalin fixed paraffin embedded tissues requires boiling the tissue sections in 10 mM citrate buffer, pH 6, for 10-20 minutes followed by cooling at RT for 20 minutes. Positive control: Western Blot: ML-1 or Raji cells.
Presentation
PBS, pH 7.4, 0.09% Sodium Azide, 40% Glycerol, 0.2% BSA
Storage
Store at 4°C or -20°C. Avoid freeze-thaw cycles.
Restrictions
For research use only.
About MCL1 / MCL 1
Myeloid cell leukimia-1 (Mcl-1) is a member of the Bcl-2 family of proteins that can act to promote cell survival. While the mechanism by which Mcl-1 inhibits apoptosis is not known, it is thought that it may heterodimerize and neutralize pro-apoptotic members of the Bcl-2 family such as Bim or Bak. Mcl-1 was originally identified in differentiating myeloid cells, but has since been shown to be expressed in multiple cell types. Q07820 NM_021960 NP_068779.1


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Requested From: United States
Date Requested: 11/15/2018

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