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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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MCL1 / MCL 1 Antibody (aa1‑327) LS‑C8946
MCL 1 antibody LS-C8946 is an unconjugated mouse monoclonal antibody to human MCL 1 (MCL1). Validated for IP and WB.
Antibody
Catalog
Size
Price
LS-C8946-250
250 µl (0.2 mg/ml)
$425
LS-C8946-500
500 µl
$635

Popular MCL1 / MCL 1 Products

Anti-MCL1 / MCL 1 antibody IHC staining of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B10210 concentration 10 ug/ml.
Species: Human
Applications: IHC, IHC - Paraffin, Immunofluorescence, Western blot, Flow Cytometry
Anti-MCL1 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B586 concentration 2 ug/ml.
Species: Human, Mouse, Rat
Applications: IHC, IHC - Paraffin, ICC, Immunofluorescence, Western blot
IHC of paraffin-embedded human lymph node showing cytoplasmic localization using MCL-1 antibody with DAB staining.
Species: Human
Applications: IHC, IHC - Paraffin, IHC - Frozen, Western blot, ELISA
Antibody
Species: Human, Mouse
Applications: IHC, Western blot, Flow Cytometry, ELISA
Anti-MCL1 antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B5215 dilution 1:25.
Species: Human
Applications: IHC, IHC - Paraffin

Product Description

MCL 1 antibody LS-C8946 is an unconjugated mouse monoclonal antibody to human MCL 1 (MCL1). Validated for IP and WB.
About MCL1 / MCL 1
Myeloid cell leukimia-1 (Mcl-1) is a member of the Bcl-2 family of proteins that can act to promote cell survival. While the mechanism by which Mcl-1 inhibits apoptosis is not known, it is thought that it may heterodimerize and neutralize pro-apoptotic members of the Bcl-2 family such as Bim or Bak. Mcl-1 was originally identified in differentiating myeloid cells, but has since been shown to be expressed in multiple cell types. Q07820 NM_021960 NP_068779.1

MCL1 Antibody, BCL2L3 Antibody, Bcl-2-like protein 3 Antibody, Bcl-2-related protein EAT/mcl1 Antibody, Bcl2-L-3 Antibody, MCL1S Antibody, MCL1L Antibody, Myeloid cell leukemia ES Antibody, MCL 1 Antibody, MCL1-ES Antibody, TM Antibody, EAT Antibody, Mcl-1 Antibody


Specifications

Target
Human MCL1 / MCL 1
Host
Mouse
Reactivity
Human (tested or 100% immunogen sequence identity)
Clonality
IgG1,k Monoclonal
Conjugations
Unconjugated
Purification
Protein G purified
Modifications
Unmodified
Applications
  • Western blot (1 - 2 µg/ml)
  • Immunoprecipitation
Failed Applications
  • IHC - Paraffin
Immunogen
MCL1 / MCL 1 antibody was raised against recombinant human Mcl-1 protein corresponding to aa1-327.
Epitope
aa1-327
Specificity
Recognizes human Mcl-1 at 42kD.
Usage
Suitable for use in Immunoprecipitation, Western Blot and Immunohistochemistry. Immunoprecipitation (Denatured verified): 2 ug/mg protein lysate (Use Protein G). Western Blot: 1-2 ug/ml for 2 hours at RT. Immunohistochemistry (Formalin/paraffin): 1:25 for 30 minutes at RT. Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM citrate buffer, pH 6.0 for 10-20 minutes followed by cooling at RT for 20 minutes. Positive control: Raji cells. Spleen or tonsil.
Presentation
PBS, pH 7.4, 0.1% Sodium Azide, 40% Glycerol, 0.2% BSA
Storage
Store at 4°C or -20°C. Avoid freeze-thaw cycles.
Restrictions
For research use only.

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Requested From: United States
Date Requested: 9/24/2018

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