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MCAM / CD146
melanoma cell adhesion molecule
Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration.
| Gene Name: | melanoma cell adhesion molecule |
| Family/Subfamily: | Immunoglobulin , not assigned-Immunoglobulin |
| Synonyms: | MCAM, CD146, CD146 antigen, Gicerin, Melanoma adhesion molecule, MUC18, p1h12 |
| Target Sequences: | NM_006500 NP_006491.2 P43121 |
Publications (3)
1
Melanoma Cell Galectin-1 Ligands Functionally Correlate with Malignant Potential. Yazawa EM, Geddes-Sweeney JE, Cedeno-Laurent F, Walley KC, Barthel SR, Opperman MJ, Liang J, Lin JY, Schatton T, Laga AC, Mihm MC, Qureshi AA, Widlund HR, Murphy GF, Dimitroff CJ. The Journal of investigative dermatology. 2015 135:1849-1862. (WB; Human)
[Full Text Article]
[PubMed:25756799]
[PMC:PMC4466041]
Related Antibodies: LS-B4050.
2
TDP-43 Vasculopathy in the Spinal Cord in Sporadic Amyotrophic Lateral Sclerosis (sALS) and Frontal Cortex in sALS/FTLD-TDP. Isidro Ferrer , Pol Andrés-Benito , Margarita Carmona , Abdelilah Assialioui, Mónica Povedano. Journal of neuropathology and experimental neurology. 2021 Feb;80:229-239. [Full Text Article]
[PubMed:33421065]
[PMC:PMC7899266]
Related Antibodies: LS-B10746.
3
Hepatic stellate cells support hematopoiesis and are liver-resident mesenchymal stem cells. Claus Kordes, Iris Sawitza, Silke Götze, Dieter Häussinger. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. 2013 March;31:290-304. [Full Text Article]
[PubMed:23485574]
Related Antibodies: LS-C35841.
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MCAM / CD146 Mouse anti-Human Monoclonal (P1H12) Antibody
Human
Flo, IHC, IHC-Fr, IHC-P, IP, WB
Unconjugated
50 µg/$460
Cancer
MCAM / CD146 Mouse anti-Human Monoclonal (aa84-189) (6C3E6) Antibody
Human
ELISA, Flo, IHC, IHC-P, WB
Unconjugated
100 µl/$485
MCAM / CD146 Mouse anti-Rat Monoclonal (aa19-560) Antibody
Rat
ELISA, Flo, WB
Unconjugated
100 µg/$872
MCAM / CD146 Rabbit anti-Human Polyclonal (Tyr641) Antibody
Human
IHC, IHC-P, WB
Unconjugated
50 µg/$460
MCAM / CD146 Rabbit anti-Human Polyclonal (aa289-338) Antibody
Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
Sandwich
96-Well Strip Plate
Rat
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Tissue Supernatants
1 Plate/$783
MCAM / CD146 Rabbit anti-Human Polyclonal (aa161-189) Antibody
Human
Flo, IHC, IHC-P, WB
Unconjugated
400 µl/$393
MCAM / CD146 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, Flo, ICC, IF, IHC, IHC-P
Unconjugated
20 µl/$286; 100 µl/$435
MCAM / CD146 Rabbit anti-Human Monoclonal Antibody
Human
ELISA, Flo, IF, IHC, IHC-P, WB
Unconjugated
50 µl/$316; 100 µl/$386
MCAM / CD146 Rabbit anti-Human Polyclonal (aa532-558) (PE) Antibody
Human
ELISA, IHC, WB
PE Conjugated
200 µl/$952
Cancer
MCAM / CD146 Mouse anti-Human Monoclonal (aa84-189) (6C3F1) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
100 µg/$485
MCAM / CD146 Rabbit anti-Mouse Monoclonal (FITC) (241) Antibody
Mouse
Flo
FITC Conjugated
25 Tests/$278; 100 Tests/$376
MCAM / CD146 Mouse anti-Human Monoclonal (Biotin) Antibody
Rabbit, Mouse, Dog, Human
ELISA, Flo, ICC, IHC, IP
Biotin Conjugated
100 µg/$842
MCAM / CD146 Mouse anti-Human Monoclonal (Azide-free) Antibody
Human
ELISA, Flo, IHC, IHC-Fr
Unconjugated, Azide-free
1 mg/$1,019
MCAM / CD146 Mouse anti-Human Monoclonal (P1H12) Antibody
Rabbit, Mouse, Canine, Human
Flo, ICC, IHC-Fr, IHC-P, IP, WB
Unconjugated
0.1 mg/$302
MCAM / CD146 Mouse anti-Human Monoclonal (PE) (P1H12) Antibody
Rabbit, Mouse, Canine, Human
Flo, ICC, IHC-Fr, IHC-P, IP, WB
PE Conjugated
100 Tests/$365
Sandwich
96-Well Strip Plate
Human
1.56 - 100 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$798
MCAM / CD146 Mouse anti-Human Monoclonal (OTI5C4) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$434
MCAM / CD146 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
MCAM / CD146 Mouse anti-Chicken Monoclonal (FITC) Antibody
Chicken
Flo, IHC, IHC-Fr, IP
FITC Conjugated
500 µg/$658
MCAM / CD146 Rabbit anti-Human Monoclonal (FITC) (044) Antibody
Human
Flo, ICC, IF
FITC Conjugated
25 Tests/$278; 100 Tests/$353
MCAM / CD146 Rabbit anti-Mouse Monoclonal (Preservative Free) (241) Antibody
Mouse
ELISA, Flo
Unconjugated, Preservative Free
100 µl/$412
MCAM / CD146 Sheep anti-Mouse Polyclonal (Extracellular Domain) Antibody
Mouse
ELISA, WB
Unconjugated
100 µg/$930
MCAM / CD146 Rabbit anti-Mouse Polyclonal (aa224-464) Antibody
Mouse
WB
Unconjugated
100 µl/$306; 200 µl/$347; 500 µl/$484; 1 ml/$553; 2 ml/$737; 5 ml/$1,206
MCAM / CD146 Mouse anti-Human Monoclonal (Azide-free, BSA-free) (MUC18/1130) Antibody
Human
Flo, IF, IHC, IHC-P
Unconjugated, Azide-free, BSA-free
100 µg/$574
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