Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
(tested or 100% immunogen sequence identity)
Western blot (1:1000 - 1:5000)
ELISA (1:10000 - 1:100000)
14 aa peptide mapping near the C-terminal 4th cytoplasmic domain of human MC4-R. This peptide sequence is 100% identical in monkey, pig, and bovine, 84% with mouse, and 69% homologous with rat MC4-R. No significant sequence homology of MCR42 is seen with other melanocortin receptors.
Recognizes human MC4-R.
Suitable for use in ELISA, Western Blot. Western Blot: 1:1000-1:5000. ELISA: 1:10000-1:100000 using 50-100 ng of control peptide/well.
PBS, pH 7.2, 0.05% Sodium Azide, 40% Glycerol
Short term: 4°C. Long term: Store at -20°C. Avoid freeze-thaw cycles.
Receptor specific to the heptapeptide core common to adrenocorticotropic hormone and alpha-, beta-, and gamma-MSH. Plays a central role in energy homeostasis and somatic growth. This receptor is mediated by G proteins that stimulate adenylate cyclase (cAMP).