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MBNL1 / MBNL
muscleblind-like splicing regulator 1
Mediates pre-mRNA alternative splicing regulation. Acts either as activator or repressor of splicing on specific pre-mRNA targets. Inhibits cardiac troponin-T (TNNT2) pre-mRNA exon inclusion but induces insulin receptor (IR) pre-mRNA exon inclusion in muscle. Antagonizes the alternative splicing activity pattern of CELF proteins. Regulates the TNNT2 exon 5 skipping through competition with U2AF2. Inhibits the formation of the spliceosome A complex on intron 4 of TNNT2 pre-mRNA. Binds to the stem-loop structure within the polypyrimidine tract of TNNT2 intron 4 during spliceosome assembly. Binds to the 5'-YGCU(U/G)Y-3'consensus sequence. Binds to the IR RNA. Binds to expanded CUG repeat RNA, which folds into a hairpin structure containing GC base pairs and bulged, unpaired U residues.
| Gene Name: | muscleblind-like splicing regulator 1 |
| Synonyms: | MBNL1, EXP35, EXP40, KIAA0428, Muscleblind (Drosophila)-like, Muscleblind-like protein 1, MBNL, EXP, EXP42, Muscleblind-like (Drosophila) |
| Target Sequences: | NM_021038 NP_066368.2 Q9NR56 |
Publications (3)
1
Ribonuclear inclusions in skeletal muscle in myotonic dystrophy types 1 and 2. Mankodi A, Teng-Umnuay P, Krym M, Henderson D, Swanson M, Thornton CA. Annals of neurology. 2003 54:760-8.
[PubMed:14681885]
2
Large-scale remodeling of a repressed exon ribonucleoprotein to an exon definition complex active for splicing. Wongpalee SP, Vashisht A, Sharma S, Chui D, Wohlschlegel JA, Black DL. eLife. 2016 5: (WB; Human)
[Full Text Article]
[PubMed:27882870]
[PMC:PMC5122456]
Related Antibodies: LS-B4372.
3
Extensive alternative splicing transitions during postnatal skeletal muscle development are required for calcium handling functions. Brinegar AE, Xia Z, Loehr JA, Li W, Rodney GG, Cooper TA. eLife. 2017 6: (WB; Human)
[Full Text Article]
[PubMed:28826478]
[PMC:PMC5577920]
Related Antibodies: LS-C30810.
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MBNL1 / MBNL Mouse anti-Human Monoclonal (3E7) Antibody
Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
50 µg/$460
E. coli
6His-SUMO, N-terminus
57 kD
1 mg/$1,355; 100 µg/$420; 20 µg/$323
MBNL1 / MBNL Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
WB
Unconjugated
100 µl/$397
MBNL1 / MBNL Rabbit anti-Human Polyclonal (aa211-260) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$424
MBNL1 / MBNL Rabbit anti-Human Polyclonal (aa211-260) (HRP) Antibody
Xenopus, Chicken, Zebrafish, Pig, Horse, Rabbit, Dog, Bat, Rat, Gibbon, Human, Monkey, Chimpanzee
IHC, IHC-P, WB
HRP Conjugated
100 µl/$469
MBNL1 / MBNL Rabbit anti-Human Polyclonal (aa211-260) (Biotin) Antibody
Xenopus, Chicken, Zebrafish, Pig, Horse, Rabbit, Dog, Bat, Rat, Gibbon, Human, Monkey, Chimpanzee
IHC, IHC-P, WB
Biotin Conjugated
100 µl/$469
MBNL1 / MBNL Rabbit anti-Human Polyclonal (aa211-260) (FITC) Antibody
Xenopus, Chicken, Zebrafish, Pig, Horse, Rabbit, Dog, Bat, Rat, Gibbon, Human, Monkey, Chimpanzee
IHC, IHC-P, WB
FITC Conjugated
100 µl/$469
MBNL1 / MBNL Mouse anti-Human Monoclonal Antibody
Mouse, Rat, Human
ELISA, WB
Unconjugated
100 µg/$680
MBNL1 / MBNL Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
50 µl/$286; 100 µl/$321; 200 µl/$386
Sandwich
96-Well Strip Plate
Human
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$783
MBNL1 / MBNL Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, WB
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
MBNL1 / MBNL Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
MBNL1 / MBNL Rabbit anti-Human Polyclonal (aa255-284) Antibody
Human
ELISA, WB
Unconjugated
200 µl/$734
MBNL1 / MBNL Rabbit anti-Human Polyclonal (aa255-284) (Biotin) Antibody
Human
ELISA, WB
Biotin Conjugated
200 µl/$952
MBNL1 / MBNL Rabbit anti-Human Polyclonal (aa255-284) (FITC) Antibody
Human
ELISA, WB
FITC Conjugated
200 µl/$952
MBNL1 / MBNL Rabbit anti-Human Polyclonal (aa255-284) (APC) Antibody
Human
ELISA, WB
APC Conjugated
200 µl/$952
MBNL1 / MBNL Rabbit anti-Human Polyclonal (aa255-284) (Azide-free) (HRP) Antibody
Human
ELISA, WB
HRP Conjugated, Azide-free
200 µl/$952
MBNL1 / MBNL Rabbit anti-Human Polyclonal (aa255-284) (PE) Antibody
Human
ELISA, WB
PE Conjugated
200 µl/$952
MBNL1 / MBNL Rabbit anti-Human Polyclonal (aa362-388) Antibody
Human
Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
MBNL1 / MBNL Goat anti-Human Polyclonal (aa375-387) Antibody
Chicken, Bovine, Hamster, Pig, Horse, Bat, Rabbit, Mouse, Dog, Human, Monkey
Peptide-ELISA, WB
Unconjugated
100 µg/$503
Wheat Germ Extract
GST
63.47 kDa
10 µg/$479; 25 µg/$670
MBNL1 / MBNL Mouse anti-Human Monoclonal (aa116-182) Antibody
Human
IF, WB
Unconjugated
100 µl/$924
MBNL1 / MBNL Rabbit anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
50 µg/$294; 100 µg/$360
MBNL1 / MBNL Rabbit anti-Human Polyclonal (HRP) Antibody
Human
ELISA, WB
HRP Conjugated
50 µg/$294; 100 µg/$360
MBNL1 / MBNL Rabbit anti-Human Polyclonal (Biotin) Antibody
Human
ELISA, WB
Biotin Conjugated
50 µg/$294; 100 µg/$360
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