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MAPT / Tau

microtubule-associated protein tau

Tau promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization. In Alzheimer disease, the neuronal cytoskeleton in the brain is progressively disrupted and replaced by tangles of paired helical filaments (PHF) and straight filaments, mainly composed of hyperphosphorylated forms of TAU.

Gene Name: microtubule-associated protein tau
Synonyms: MAPT, FTDP-17, MSTD, Neurofibrillary tangle protein, PHF-tau, MTBT2, PPND, DDPAC, MAPTL, MTBT1, Paired helical filament-tau, TAU
Target Sequences: NM_016835 P10636

Publications (3)

1
Hyperphosphorylation and aggregation of Tau in laforin-deficient mice, an animal model for Lafora disease. Puri R, Suzuki T, Yamakawa K, Ganesh S. The Journal of biological chemistry. 2009 284:22657-63. (IHC, WB) [PubMed:19542233] [PMC:PMC2755673]
2
Effect of carbamylated erythropoietin on major histocompatibility complex expression and neural differentiation of human neural stem cells. Fu ZQ, Shao QL, Shen JL, Zhang YJ, Zhao XX, Yao L. Journal of neuroimmunology. 2010 221:15-24. (ICC, WB) [PubMed:20163877]
3
Serum levels of tau protein increase according to the severity of the injury in DAI rat model. Keisuke Tomita, Taka-Aki Nakada, Taku Oshima, Rui Kawaguchi, Shigeto Oda. F1000Research. 2020 December;9:29. [Full Text Article] [PubMed:33299544] [PMC:PMC7707115]

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MAPT / Tau Antibody - Human Brain, Cortex: Formalin-Fixed, Paraffin-Embedded (FFPE)
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Cancer Pathology
Cancer
MAPT / Tau Mouse anti-Human Monoclonal (MCA-2E9) Antibody
Mouse, Rat, Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
50 µl/$460
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MAPT / Tau Rabbit anti-Human Polyclonal (aa677-707) Antibody
Human
ELISA, IHC, WB
Unconjugated
200 µl/$734
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MAPT / Tau Rabbit anti-Human Polyclonal (aa677-707) (Azide-free) (HRP) Antibody
Human
ELISA, IHC, WB
HRP Conjugated, Azide-free
200 µl/$952
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MAPT / Tau Rabbit anti-Human Polyclonal (680-760 aa) Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
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MAPT / Tau Mouse anti-Human Monoclonal (Preservative Free) Antibody
Human
ELISA, WB
Unconjugated, Preservative Free
20 µg/$242; 100 µg/$304; 200 µg/$334; 500 µg/$452
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MAPT / Tau Mouse anti-Human Monoclonal (Preservative Free) (Biotin) Antibody
Human
ELISA, WB
Biotin Conjugated, Preservative Free
50 µg/$343
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MAPT / Tau Mouse anti-Human Monoclonal Antibody
Rat, Human
WB
Unconjugated
100 µg/$880
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MAPT / Tau Mouse anti-Bovine Monoclonal (Magnetic beads) (TAU-93) Antibody
Mouse, Bovine, Rat, Human
IP
Magnetic beads Conjugated
100 µg/$399
MAPT / Tau Antibody - Immunocytochemistry/Immunofluorescence analysis using Rabbit Anti-Tau Monoclonal Antibody, Clone AH36. Tissue: iPSC-derived cortical excitatory neurons. Species: Human. Primary Antibody: Rabbit Anti-Tau Monoclonal Antibody at 1:500 for Overnight. Secondary Antibody: Donkey anti-rabbit: Alexa Fluor 488 at 1:1000. Counterstain: DAPI. A) iPSC-derived neurons from non-demented control (NDC). B) iPSC-derived neurons from subject with P301L MAPT mutation. Images acquired using an automated Opera Phoenix system. Each field of view is a max projection from 10 planes of 1 µm stacks. Courtesy of: Francesco Paonessa.
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MAPT / Tau Rabbit anti-Human Monoclonal (pSer202/pThr205) (AH36) Antibody
Human
DB, ELISA, IF, WB
Unconjugated
100 µg/$544
MAPT / Tau Antibody - Human Brain, Cortex: Formalin-Fixed, Paraffin-Embedded (FFPE)
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MAPT / Tau Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IHC, IHC-P, WB
Unconjugated
0.05 mg/$440
MAPT / Tau ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
15.625 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$768
MAPT / Tau Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
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Yeast
6His, N-terminus
100 µg/$570; 20 µg/$395; 1 mg/$1,973
MAPT / Tau ELISA Kit
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Sandwich
96-Well Strip Plate
Human
7.8 - 500 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$783
MAPT / Tau ELISA Kit
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Sandwich
96-Well Microplate
Human
7.81 - 500 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$771
MAPT / Tau ELISA Kit
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Sandwich
96-Well Microplate
Rat
31.25 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$651
MAPT / Tau ELISA Kit
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Sandwich
96-Well Microplate
Pig
62.5 - 4000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$863
MAPT / Tau ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
15.6 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$783
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E. coli
His-SUMO
63.8 kD
1 mg/$1,679; 100 µg/$598; 20 µg/$405
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E. coli
None
Less than 1.0 EU/µg protein (determined by LAL method).
45.85kD
10 µg/$288; 50 µg/$442; 500 µg/$1,585; 1 mg/$2,157
MAPT / Tau ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Tissue Homogenates
1 Plate/$818
MAPT / Tau ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
31.2 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$798
MAPT / Tau ELISA Kit
Select
Sandwich
96-Well Microplate
Mouse
15.63 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$651
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MAPT / Tau Mouse anti-Human Monoclonal (pThr231) (13B10) Antibody
Human
ELISA, IP, WB
Unconjugated
20 µg/$242; 100 µg/$304; 200 µg/$334; 500 µg/$452
MAPT / Tau Antibody - Human Brain, Cortex: Formalin-Fixed, Paraffin-Embedded (FFPE)
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MAPT / Tau Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Mouse, Dog, Bovine, Rat, Pig, Human
ICC, IF, IHC, IHC-P, IP, WB
Unconjugated
50 µl/$460
MAPT / Tau Antibody - Western blot analysis of extracts from rat brain cells, using Tau (Phospho-Thr534/217) antibody.
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MAPT / Tau Rabbit anti-Human Polyclonal (pThr534/217) Antibody
Mouse, Rat, Human
ELISA, WB
Unconjugated
100 µg/$357
Viewing 1-25 of 423 product results



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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).