Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Human (tested or 100% immunogen sequence identity)
Monkey, Dog, Horse (at least 90% immunogen sequence identity)
IHC (5 µg/ml)
Western blot (5 µg/ml)
Specificity and Use
MAPT / Tau antibody was raised against a synthetic peptide for the N terminus portion (AEPRQEFEVMEDHAG) of human tau protein. Percent identity by BLAST analysis: Human, Chimpanzee, Gorilla (100%); Gibbon, Baboon, Monkey, Dog, Horse (93%); Galago, Goat, Elephant, Bovine, Pig (87%); Mouse, Rat (80%).
Human MAPT / Tau
Lyophilized from PBS, 1% BSA, 0.05% sodium azide
1 ml Distilled water
Short term 4°C, long term aliquot and store at -20°C, avoid freeze-thaw cycles.
Tau promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome.