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MAPK8IP1 / JIP1
mitogen-activated protein kinase 8 interacting protein 1
The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. Required for JNK activation in response to excitotoxic stress. Cytoplasmic MAPK8IP1 causes inhibition of JNK-regulated activity by retaining JNK in the cytoplasm and inhibiting JNK phosphorylation of c-Jun. May also participate in ApoER2-specific reelin signaling. Directly, or indirectly, regulates GLUT2 gene expression and beta-cell function. Appears to have a role in cell signaling in mature and developing nerve terminals. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins (By similarity). Functions as an anti-apoptotic protein and whose level seems to influence the beta-cell death or survival response.
| Gene Name: | mitogen-activated protein kinase 8 interacting protein 1 |
| Synonyms: | MAPK8IP1, JIP1, JNK-interacting protein 1, IB-1, IB1, Islet-brain 1, JIP-1, PRKM8 interacting protein, PRKM8IP |
| Target Sequences: | NM_005456 NP_005447.1 Q9UQF2 |
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